Abstract
Pharmacological studies with pirenzepine were carried out on the isolated ileum and atrium of the guinea-pig and on the acid secretion from the isolated stomach of the mouse. Pirenzepine inhibited the bethanechol-evoked changes in all three organs in a dose-dependent manner. The slopes of the Schild-plots confirmed the competitive nature of the antagonism by pirenzepine. The estimated pA2-values were very similar. Based on these data, it might be concluded that pirenzepine is an anticholinoceptor compound without specific affinity for gastric muscarinic receptors.
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Selected References
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- ARUNLAKSHANA O., SCHILD H. O. Some quantitative uses of drug antagonists. Br J Pharmacol Chemother. 1959 Mar;14(1):48–58. doi: 10.1111/j.1476-5381.1959.tb00928.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Angus J. A., Black J. W. Analysis of anomalous pKb values for metiamide and atropine in the isolated stomach of the mouse. Br J Pharmacol. 1979 Sep;67(1):59–65. [PMC free article] [PubMed] [Google Scholar]
- Daly M. J., Humphray J. M., Stables R. Effects of H2-receptor antagonists and anticholinoceptor drugs on gastric and salivary secretion induced by bethanechol in the anaesthetized dog. Br J Pharmacol. 1982 Jul;76(3):361–365. doi: 10.1111/j.1476-5381.1982.tb09228.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hammer R., Berrie C. P., Birdsall N. J., Burgen A. S., Hulme E. C. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature. 1980 Jan 3;283(5742):90–92. doi: 10.1038/283090a0. [DOI] [PubMed] [Google Scholar]
- Szelenyi I. An isolated mammalian stomach preparation for studying the effect of substances on gastric acid secretion. Arzneimittelforschung. 1981;31(6):998–1000. [PubMed] [Google Scholar]
- Szelenyi I., Vergin H. Cholinergic pathway of gastric acid secretion in the isolated whole stomach of the mouse. Pharmacology. 1980;21(4):268–276. doi: 10.1159/000137441. [DOI] [PubMed] [Google Scholar]