Abstract
McN-A-343 behaves as a competitive agonist in binding to muscarinic receptors in the cerebral cortex. In its interaction with myocardial muscarinic receptors it is not competitive but it retains features of agonist binding.
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Selected References
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- Berrie C. P., Birdsall N. J., Burgen A. S., Hulme E. C. Guanine nucleotides modulate muscarinic receptor binding in the heart. Biochem Biophys Res Commun. 1979 Apr 27;87(4):1000–1005. doi: 10.1016/s0006-291x(79)80006-6. [DOI] [PubMed] [Google Scholar]
- Birdsall N. J., Burgen A. S., Hulme E. C. The binding of agonists to brain muscarinic receptors. Mol Pharmacol. 1978 Sep;14(5):723–736. [PubMed] [Google Scholar]
- Birdsall N. J., Hulme E. C., Burgen A. The character of the muscarinic receptors in different regions of the rat brain. Proc R Soc Lond B Biol Sci. 1980 Feb 13;207(1166):1–12. doi: 10.1098/rspb.1980.0011. [DOI] [PubMed] [Google Scholar]
- Fozard J. R., Muscholl E. Effects of several muscarinic agonists on cardiac performance and the release of noradrenaline from sympathetic nerves of the perfused rabbit heart. Br J Pharmacol. 1972 Aug;45(4):616–629. doi: 10.1111/j.1476-5381.1972.tb08119.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hammer R., Berrie C. P., Birdsall N. J., Burgen A. S., Hulme E. C. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature. 1980 Jan 3;283(5742):90–92. doi: 10.1038/283090a0. [DOI] [PubMed] [Google Scholar]
- Hulme E. C., Birdsall N. J., Burgen A. S., Mehta P. The binding of antagonists to brain muscarinic receptors. Mol Pharmacol. 1978 Sep;14(5):737–750. [PubMed] [Google Scholar]
- ROSZKOWSKI A. P. An unusual type of sympathetic ganglionic stimulant. J Pharmacol Exp Ther. 1961 May;132:156–170. [PubMed] [Google Scholar]
- Rosenberger L. B., Roeske W. R., Yamamura H. I. The regulation of muscarinic cholinergic receptors by guanine nucleotides in cardiac tissue. Eur J Pharmacol. 1979 Jun;56(1-2):179–180. doi: 10.1016/0014-2999(79)90451-5. [DOI] [PubMed] [Google Scholar]
- Wei J. W., Sulakhe P. V. Agonist-antagonist interactions with rat atrial muscarinic cholinergic receptor sites: differential regulation by guanine nucleotides. Eur J Pharmacol. 1979 Sep 1;58(1):91–92. doi: 10.1016/0014-2999(79)90346-7. [DOI] [PubMed] [Google Scholar]