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. 1983 Mar;78(3):599–603. doi: 10.1111/j.1476-5381.1983.tb08820.x

Purine receptors in the guinea-pig internal anal sphincter.

A Crema, G M Frigo, S Lecchini, L Manzo, L Onori, M Tonini
PMCID: PMC2044734  PMID: 6301603

Abstract

1 In the isolated internal anal sphincter of the guinea-pig, adenosine 5'-triphosphate (ATP) and adenosine induced a concentration-dependent and tetrodotoxin-insensitive relaxation. 2 Pretreatment with theophylline (25-50 microM) had no significant effect on the concentration-response curves obtained with either purine compound. 3 Reactive blue 2 (25-100 microM) shifted the curve to ATP to the right in a dose-dependent fashion leaving that to adenosine unaltered. The antagonism appeared to be non-competitive. 4 Neither reactive blue 2 nor purine receptor occupation by ATP or adenosine altered the electrically-induced non-adrenergic, non-cholinergic inhibitory response. 5 The actions of ATP and adenosine in the guinea-pig internal anal sphincter appear to be mediated by separate receptors. These receptors are not involved in the nerve-mediated relaxation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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