Abstract
1 The effects of various anticonvulsant drugs were evaluated quantitatively on the development of the epileptogenic EEG, induced by the intravenous infusion of leptazol in rats anaesthetized with urethane. 2 Leptazol alone produced five distinct phases of EEG activity developing from early wave and small spike and wave activity to larger spikes which later grouped and led to full body convulsion (FBC). 3 Drugs effective in petit mal such as clonazepam (0.1 and 0.25 mg kg-1) and ethosuximide (100 and 200 mg kg-1), significantly delayed the time to FBC by prolonging the early phases of the epileptogenic EEG and delaying the appearance of spiking. 4 Drugs effective in grand mal such as sodium valproate (60 mg kg-1) and phenytoin (5 mg kg-1) significantly prolonged the time to FBC by extending the later phases of the EEG and the development and grouping of spikes. Higher doses of these compounds were without effect. Carbamazepine and phenobarbitone produced mixed effects but were generally not markedly anticonvulsant. 5 The model is sensitive to drugs effective in both petit mal and grand mal, and appears able to differentiate usefully between them.
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- AJMONE-MARSAN C., MAROSSERO F. Electrocorticographic and electrochordographic study of the convulsions induced by cardiazol; some observations on the combined action of C.N.S. excitants. Electroencephalogr Clin Neurophysiol. 1950 May;2(2):133–142. doi: 10.1016/0013-4694(50)90025-3. [DOI] [PubMed] [Google Scholar]
- Desmedt L. K., Niemegeers C. J., Lewi P. J., Janssen P. A. Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classification of antiepileptic drugs. Arzneimittelforschung. 1976;26(8):1592–1603. [PubMed] [Google Scholar]
- Ito T., Hori M., Yoshida K., Shimizu M. Effect of anticonvulsants on seizures developing in the course of daily administration of pentetrazol to rats. Eur J Pharmacol. 1977 Sep 15;45(2):165–172. doi: 10.1016/0014-2999(77)90086-3. [DOI] [PubMed] [Google Scholar]
- Prichard J. W. Phenobarbital: introduction. Adv Neurol. 1980;27:473–491. [PubMed] [Google Scholar]
- Rodin E., Rodin M., Lavine L. Electroclinical and ultrastructural changes associated with subconvulsant doses of pentylenetetrazol. Exp Neurol. 1979 May;64(2):386–400. doi: 10.1016/0014-4886(79)90278-4. [DOI] [PubMed] [Google Scholar]
- Woodbury D. M. Convulsant drugs: mechanisms of action. Adv Neurol. 1980;27:249–303. [PubMed] [Google Scholar]
- Woodbury D. M. Phenytoin: proposed mechanisms of anticonvulsant action. Adv Neurol. 1980;27:447–471. [PubMed] [Google Scholar]