Abstract
1 The concentration of copper in serum and liver was determined by atomic absorption spectrophotometry in a study performed on normal rats of either sex and in female rats with carrageenan-induced pleurisy. 2. In the normal animal, total serum copper concentration is significantly higher in female rats, and appears to be higher in mature animals in females. 3 In normal rats of either sex, liver copper concentration undergoes daily variations which are inversely related to the weight of the organ and which leave constant the total amount of metal in the liver. Moreover a day to day non-cyclic variability of liver copper concentration and liver weight was observed. 4 This first set of data showed that comparison with time control was essential. 5 In the inflamed rat, a significant rise of total serum copper at 22, 48 and 72 h after the induction of inflammation was observed. From 96 h up to 240 h post-injection no significant differences were evident. 6 Total liver copper content did not change in the inflamed rats. 7 During acute inflammation in the rat, the copper needed for the increased synthesis of caeruloplasmin is supplied without depletion of liver copper stores.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albergoni V., Cassini A., Favero N., Rocco G. P. Effect of penicillamine on some metals and metalloproteins in the rat. Biochem Pharmacol. 1975 May 15;24(10):1131–1133. doi: 10.1016/0006-2952(75)90204-x. [DOI] [PubMed] [Google Scholar]
- Conforti A., Franco L., Milanino R., Velo G. P. Copper and ceruloplasmin (Cp) concentrations during the acute inflammatory process in the rat. Agents Actions. 1982 Jul;12(3):303–307. doi: 10.1007/BF01965394. [DOI] [PubMed] [Google Scholar]
- Milanino R., Conforti A., Fracasso M. E., Franco L., Leone R., Passarella E., Tarter G., Velo G. P. Concerning the role of endogenous copper in the acute inflammatory process. Agents Actions. 1979 Dec;9(5-6):581–588. doi: 10.1007/BF01968131. [DOI] [PubMed] [Google Scholar]
- Milanino R., Mazzoli S., Passarella E., Tarter G., Velo G. P. Carrageenan oedema in copper-deficient rats. Agents Actions. 1978 Dec;8(6):618–622. doi: 10.1007/BF01998891. [DOI] [PubMed] [Google Scholar]
- Scudder P. R., Al-Timimi D., McMurray W., White A. G., Zoob B. C., Dormandy T. L. Serum copper and related variables in rheumatoid arthritis. Ann Rheum Dis. 1978 Feb;37(1):67–70. doi: 10.1136/ard.37.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sorenson J. R. Copper complexes - a unique class of anti-arthritic drugs. Prog Med Chem. 1978;15:211–260. doi: 10.1016/s0079-6468(08)70257-1. [DOI] [PubMed] [Google Scholar]
- WINTROBE M. M., CARTWRIGHT G. E., GUBLER C. J. Studies on the function and metabolism of copper. J Nutr. 1953 Aug;50(4):395–419. doi: 10.1093/jn/50.4.395. [DOI] [PubMed] [Google Scholar]