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. 1983 Oct;80(2):225–228. doi: 10.1111/j.1476-5381.1983.tb10023.x

Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones.

R A North, J T Williams
PMCID: PMC2045013  PMID: 6652378

Abstract

Opiates act on mu-receptors to increase the potassium conductance of rat locus coeruleus neurones. Opiates also depress the rate of rise and peak amplitude of calcium action potentials in these cells. The action of opiates on calcium action potentials was prevented by two procedures which blocked the opiate-induced potassium current, intracellular caesium and extracellular barium. This indicates that the opiate reduction in calcium entry is secondary to an increased potassium current.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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