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. 1983 Dec;80(4):691–697. doi: 10.1111/j.1476-5381.1983.tb10059.x

Heterogeneity of 5-hydroxytryptamine receptors in the rat uterus and stomach strip.

S J Wrigglesworth
PMCID: PMC2045060  PMID: 6571226

Abstract

Experiments were performed using the rat isolated uterus and the rat stomach strip to investigate the effects of 5-hydroxytryptamine (5-HT) on 5-HT receptors in the presence of different antagonists. Amitriptyline, methysergide and trazodone were used to antagonize the response to 5-HT in these tissues. The pA2 value for amitriptyline with 5-HT as the agonist was estimated from the Schild plot analysis and found to differ significantly (P less than 0.05) in the stomach strip (6.36) from that in the isolated uterus (9.06). A similar difference was found using trazodone; here the pA2 value was 6.74 in the stomach strip and 8.49 in the isolated uterus. These results indicate a difference between the two tissues. This difference is discussed in terms of heterogeneity of 5-HT receptors.

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Selected References

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