Abstract
The time sequence of changes in total and differential white blood cell counts in dogs subjected to hemorrhagic shock are described and are correlated with alterations in the ultrastructure of intravascular neutrophilic polymorphonuclear leukocytes in the lungs of the same dogs. Total circulating white blood cells fall to 20% of control values and neutrophils fall to 10% of control values in hemorrhagic shock; these values do not return to control levels after reinfusion of shed blood. Intravascular neutrophils in the lung are increased in number after hemorrhagic shock and exhibit alterations in ultrastructure which include loss of density in the cell sap, loss of density in granules and unusual apposition between the plasma membranes of netrophils and adjacent endothelial cells. The results are interpreted as suggesting that circulating neutrophils become “sticky” in hemorrhagic shock; that the lung exerts a sieving effect on these cells; that obstruction of alveolar capillaries by these cells may account for certain abnormalities in the alveolar microcirculation in shock; and that these results may explain the observation that the isolated lung is protected from the deleterious effects of hemorrhagic shock.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALLISON F., Jr, LANCASTER M. G., CROSTHWAITE J. L. STUDIES ON THE PATHOGENESIS OF ACUTE INFLAMMATION. V. AN ASSESSMENT OF FACTORS THAT INFLUENCE IN VITRO THE PHAGOCYTIC AND ADHESIVE PROPERTIES OF LEUKOCYTES OBTAINED FROM RABBIT PERITONEAL EXUDATE. Am J Pathol. 1963 Nov;43:775–795. [PMC free article] [PubMed] [Google Scholar]
- Eiseman B. Pulmonary effects of nonthoracic trauma. Introduction to conference. J Trauma. 1968 Sep;8(5):649–650. [PubMed] [Google Scholar]
- Glenn T. M., Lefer A. M. Anti-toxic action of methylprednisolone in hemorrhagic shock. Eur J Pharmacol. 1971 Jan;13(2):230–238. doi: 10.1016/0014-2999(71)90154-3. [DOI] [PubMed] [Google Scholar]
- JANOFF A., WEISSMANN G., ZWEIOFACH B. W., THOMAS L. Pathogenesis of experimental shock. IV. Studies on lysosomes in normal and tolerant animals subjected to lethal trauma and endotoxemia. J Exp Med. 1962 Oct 1;116:451–466. doi: 10.1084/jem.116.4.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KNISELY W. H., WALLACE J. M., MAHALEY M. S., Jr, SATTERWHITE W. M., Jr Evidence, including in vivo observations, suggesting mechanical blockage rather than reflex vasospasm as the cause of death in pulmonary embolization. Am Heart J. 1957 Oct;54(4):482–497. doi: 10.1016/0002-8703(57)90289-2. [DOI] [PubMed] [Google Scholar]
- MARCHESI V. T. The site of leucocyte emigration during inflammation. Q J Exp Physiol Cogn Med Sci. 1961 Apr;46:115–118. doi: 10.1113/expphysiol.1961.sp001522. [DOI] [PubMed] [Google Scholar]
- Ratliff N. B., Wilson J. W., Hackel D. B., Martin A. M., Jr The lung in hemorrhagic shock. II. Observations on alveolar and vascular ultrastructure. Am J Pathol. 1970 Feb;58(2):353–373. [PMC free article] [PubMed] [Google Scholar]
- Willwerth B. M., Crawford F. A., Young W. G., Jr, Sealy W. C. The role of functional demand on the development of pulmonary lesions during hemorrhagic shock. J Thorac Cardiovasc Surg. 1967 Nov;54(5):658–665. [PubMed] [Google Scholar]
- Wilson J. W., Ratliff N. B., Hackel D. B. The lung in hemorrhagic shock. I. In vivo observations of pulmonary microcirculation in cats. Am J Pathol. 1970 Feb;58(2):337–351. [PMC free article] [PubMed] [Google Scholar]