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. 1971 Nov;65(2):411–424.

Transfer Amyloidosis

I. Studies on the Transfer of Various Lymphoid Cells from Amyloidotic Mice to Syngeneic Nonamyloidotic Recipients and II. Induction of Amyloidosis in Mice with Spleen, Thymus and Lymph Node Tissue from Casein-Sensitized Syngeneic Donors

Finn Hardt
PMCID: PMC2047444  PMID: 4944153

Abstract

Lymphoid cells from various lymphoid organs were transferred from amyloidotic mice to normal syngeneic recipients. The recipients were treated with nitrogen mustard. Only the recipients of spleen cells developed amyloidosis. Furthermore, slices of spleen, thymus and lymph node from casein-sensitized mice were transplanted to kidneys of normal syngeneic mice. The recipients were treated with ten casein injections, and they all developed amyloidosis. The results from both experiments indicate that amyloid is formed by macrophages due to a stimulation of these cells with both antigen and an amyloid-inducing factor released from the pyroninophilic lymphoid cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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