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. 1970 Dec;61(3):413–436.

Effects of choline-deficient diets on the rat hepatocyte. Electron microscopic observations.

C Bruni, D M Hegsted
PMCID: PMC2047449  PMID: 4340541

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARTOM C. Rôle of choline in the oxidation of fatty acids by the liver. J Biol Chem. 1953 Nov;205(1):101–111. [PubMed] [Google Scholar]
  2. Blumenstein J. Studies in phospholipid metabolism. 2. Incorporation of metabolic precursors of phospholipids in choline deficiency. Can J Physiol Pharmacol. 1968 May;46(3):487–494. doi: 10.1139/y68-071. [DOI] [PubMed] [Google Scholar]
  3. Bruni C., Porter K. R. The Fine Structure of the Parenchymal Cell of the Normal Rat Liver: I. General Observations. Am J Pathol. 1965 May;46(5):691–755. [PMC free article] [PubMed] [Google Scholar]
  4. Estes L., Lombardi B. Effect of choline deficiency on the Golgi apparatus of rat hepatocytes. Lab Invest. 1969 Nov;21(5):374–385. [PubMed] [Google Scholar]
  5. HAINES D. S., MOOKERJEA S. IMPAIRMENT OF TRIGLYCERIDE TRANSPORT FROM THE LIVER IN CHOLINE DEFICIENCY. Can J Biochem. 1965 Apr;43:507–520. doi: 10.1139/o65-059. [DOI] [PubMed] [Google Scholar]
  6. HARTROFT W. S. Pathology of lipid disorders: liver and cardiovascular system. Fed Proc. 1961 Mar;20(Suppl 7):135–145. [PubMed] [Google Scholar]
  7. Hegsted D. M., Roach A. M., McCombs H. L. Effect of vitamin B-12 in choline deficiency in the rat. J Nutr. 1967 Jul;92(3):403–411. doi: 10.1093/jn/92.3.403. [DOI] [PubMed] [Google Scholar]
  8. Johnston J. M., Rao G. A., Lowe P. A., Schwarz B. E. The nature of the stimulatory role of the supernatant fraction on triglyceride synthesis by the alpha-Glycerophosphate pathway. Lipids. 1967 Jan;2(1):14–20. doi: 10.1007/BF02531994. [DOI] [PubMed] [Google Scholar]
  9. Jones A. L., Ruderman N. B., Herrera M. G. Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J Lipid Res. 1967 Sep;8(5):429–446. [PubMed] [Google Scholar]
  10. Lombardi B., Oler A. Choline deficiency fatty liver. Protein synthesis and release. Lab Invest. 1967 Sep;17(3):308–321. [PubMed] [Google Scholar]
  11. Lombardi B., Pani P., Schlunk F. F. Choline-deficiency fatty liver: impaired release of hepatic triglycerides. J Lipid Res. 1968 Jul;9(4):437–446. [PubMed] [Google Scholar]
  12. Mahley R. W., Hamilton R. L., Lequire V. S. Characterization of lipoprotein particles isolated from the Golgi apparatus of rat liver. J Lipid Res. 1969 Jul;10(4):433–439. [PubMed] [Google Scholar]
  13. Mookerjea S. Studies on the rapid accumulation of triglyceride in the liver in choline deficiency. Can J Biochem. 1965 Oct;43(10):1733–1744. doi: 10.1139/o65-192. [DOI] [PubMed] [Google Scholar]
  14. NESTEL P. J., STEINBERG D. FATE OF PALMITATE AND OF LINOLEATE PERFUSED THROUGH THE ISOLATED RAT LIVER AT HIGH CONCENTRATIONS. J Lipid Res. 1963 Oct;4:461–469. [PubMed] [Google Scholar]
  15. Omura T., Siekevitz P., Palade G. E. Turnover of constituents of the endoplasmic reticulum membranes of rat hepatocytes. J Biol Chem. 1967 May 25;242(10):2389–2396. [PubMed] [Google Scholar]
  16. Porta E. A., Manning C., Hartroft W. S. The lipotropic action of orotic acid. Arch Pathol. 1968 Aug;86(2):217–229. [PubMed] [Google Scholar]
  17. Ruderman N. B., Richards K. C., Valles de Bourges V. Regulation of production and release of lipoprotein by the perfused rat liver. J Lipid Res. 1968 Sep;9(5):613–619. [PubMed] [Google Scholar]
  18. Smith M. E., Sedgwick B., Brindley D. N., Hübscer G. The role of phosphatidate phosphohydrolase in glyceride biosynthesis. Eur J Biochem. 1967 Dec;3(1):70–77. doi: 10.1111/j.1432-1033.1967.tb19499.x. [DOI] [PubMed] [Google Scholar]
  19. Stein O., Stein Y. Lecithin synthesis, intracellular transport, and secretion in rat liver. IV. A radioautographic and biochemical study of choline-deficient rats injected with choline-3H. J Cell Biol. 1969 Feb;40(2):461–483. doi: 10.1083/jcb.40.2.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stein O., Stein Y. Lipid synthesis, intracellular transport, storage, and secretion. I. Electron microscopic radioautographic study of liver after injection of tritiated palmitate or glycerol in fasted and ethanol-treated rats. J Cell Biol. 1967 May;33(2):319–339. doi: 10.1083/jcb.33.2.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. TINOCO J., SHANNON A., LYMAN R. L. SERUM LIPIDS IN CHOLINE-DEFICIENT MALE AND FEMALE RATS. J Lipid Res. 1964 Jan;5:57–62. [PubMed] [Google Scholar]
  22. TZUR R., TAL E., SHAPIRO B. ALPHA-GLYCEROPHOSPHATE AS REGULATORY FACTOR IN FATTY ACID ESTERIFICATION. Biochim Biophys Acta. 1964 Feb 24;84:18–23. doi: 10.1016/0926-6542(64)90096-4. [DOI] [PubMed] [Google Scholar]
  23. Windmueller H. G., Spaeth A. E. De novo synthesis of fatty acid in perfused rat liver as a determinant of plasma lipoprotein production. Arch Biochem Biophys. 1967 Nov;122(2):362–369. doi: 10.1016/0003-9861(67)90206-8. [DOI] [PubMed] [Google Scholar]
  24. YOSHIDA A., HARPER A. E. Effect of threonine and choline deficiencies on the metabolism of C14-labeled acetate and palmitate in the intact rat. J Biol Chem. 1960 Sep;235:2586–2589. [PubMed] [Google Scholar]

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