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. 1971 Dec;65(3):543–548.

Fatal Adenovirus Pneumonia in Infants

Correlation of Histologic and Electron Microscopic Observations

Henry Pinkerton, Shirley Carroll
PMCID: PMC2047586  PMID: 4330417

Abstract

Many structures morphologically identical with adenovirions were found in large numbers in typically altered respiratory epithelial cells in 10-year-old sections stained with hematoxylin and eosin of 2 cases of a histologically unique type of fatal pneumonia in infancy. These observations confirm, beyond reasonable doubt, an etiologic role of adenoviruses in the initiation and development of this type of pneumonia. The technic used, which was a modification of one previously described, is given in detail, since such methods may be useful in solving other etiologic problems.

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Selected References

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  1. BENYESH-MELNICK M., ROSENBERG H. S. THE ISOLATION OF ADENOVIRUS TYPE 7 FROM A FATAL CASE OF PNEUMONIA AND DISSEMINATED DISEASE. J Pediatr. 1964 Jan;64:83–87. doi: 10.1016/s0022-3476(64)80321-8. [DOI] [PubMed] [Google Scholar]
  2. Blank H., Davis C., Collins C. Electron microscopy for the diagnosis of cutaneous viral infections. Br J Dermatol. 1970;83(Suppl):69–80. doi: 10.1111/j.1365-2133.1970.tb12866.x. [DOI] [PubMed] [Google Scholar]
  3. CHANY C., LEPINE P., LELONG M., LE T. V., SATGE P., VIRAT J. Severe and fatal pneumonia in infants and young children associated with adenovirus infections. Am J Hyg. 1958 May;67(3):367–378. doi: 10.1093/oxfordjournals.aje.a119941. [DOI] [PubMed] [Google Scholar]
  4. DEINHARDT F., MAY R. D., CALHOUN H. H., SULLIVAN H. E. The isolation of adenovirus type 1 from a fatal case of viral pneumonitis. AMA Arch Intern Med. 1958 Nov;102(5):816–819. doi: 10.1001/archinte.1958.00260220132015. [DOI] [PubMed] [Google Scholar]
  5. DROUHET V. Etude d'un virus APC (adéno-virus) isolé d'un cas de pneumopathie mortelle. Ann Inst Pasteur (Paris) 1957 Jul;93(1):138–142. [PubMed] [Google Scholar]
  6. KUSANO N., KAWAI K., AOYAMA Y. Intranuclear inclusion body in fatal infantile pneumonia due to adenovirus. Jpn J Exp Med. 1958 Aug;28(4):301–304. [PubMed] [Google Scholar]
  7. Nahmias A. J., Griffith D., Snitzer J. Fatal pneumonia associated with adenovirus type 7. Am J Dis Child. 1967 Jul;114(1):36–41. doi: 10.1001/archpedi.1967.02090220042007. [DOI] [PubMed] [Google Scholar]
  8. WRIGHT H. T., Jr, BECKWITH J. B., GWINN J. L. A FATAL CASE OF INCLUSION BODY PNEUMONIA IN AN INFANT INFECTED WITH ADENOVIRUS TYPE 3. J Pediatr. 1964 Apr;64:528–533. doi: 10.1016/s0022-3476(64)80342-5. [DOI] [PubMed] [Google Scholar]

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