Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1971 Sep;64(3):675–708.

Murine chronic respiratory disease. Significance as a research complication and experimental production with Mycoplasma pulmonis.

J R Lindsey, H J Baker, R G Overcash, G H Cassell, C E Hunt
PMCID: PMC2047606  PMID: 4943862

Full text

PDF
675

Images in this article

713Fig 10
on p.713
713Fig 11
on p.713
713Fig 12
on p.713
713Fig 13
on p.713
715Fig 15
on p.715
715Fig 16
on p.715
714Fig 14
on p.714
711Fig 5
on p.711
711Fig 6
on p.711
711Fig 7
on p.711
711Figs 8 and 9
on p.711
716Fig 17
on p.716
716Fig 18
on p.716
716Fig 19
on p.716
710Fig 4
on p.710
709Fig 1
on p.709
709Fig 2
on p.709
709Fig 3
on p.709

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APPEL J. B. THE RAT: AN IMPORTANT SUBJECT. J Exp Anal Behav. 1964 Sep;7:355–356. doi: 10.1901/jeab.1964.7-355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adler H. E. Mycoplasmosis in animals. Adv Vet Sci. 1965;10:205–244. [PubMed] [Google Scholar]
  3. BERG B. N., HARMISON C. R. Growth, disease, and aging in the rat. J Gerontol. 1957 Oct;12(4):370–377. doi: 10.1093/geronj/12.4.370. [DOI] [PubMed] [Google Scholar]
  4. Barden J. A., Tully J. G. Experimental arthritis in mice with Mycoplasma pulmonis. J Bacteriol. 1969 Oct;100(1):5–10. doi: 10.1128/jb.100.1.5-10.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brennan P. C., Fritz T. E., Flynn R. J. Murine pneumonia: a review of the etiologic agents. Lab Anim Care. 1969 Jun;19(3):360–371. [PubMed] [Google Scholar]
  6. Brennan P. C., Fritz T. E., Flynn R. J. Pasteurella pneumotropica: cultural and biochemical characteristics, and its association with disease in laboratory animals. Lab Anim Care. 1965 Oct;15(5):307–312. [PubMed] [Google Scholar]
  7. Brennan P. C., Fritz T. E., Flynn R. J. Role of Pasteurella pneumotropica and Mycoplasma pulmonis in murine pneumonia. J Bacteriol. 1969 Jan;97(1):337–349. doi: 10.1128/jb.97.1.337-349.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CHENG K. K. The experimental production of bronchiectasis in rats. J Pathol Bacteriol. 1954 Jan;67(1):89–98. doi: 10.1002/path.1700670111. [DOI] [PubMed] [Google Scholar]
  9. Del Giudice R. A., Robillard N. F., Carski T. R. Immunofluorescence identification of Mycoplasma on agar by use of incident illumination. J Bacteriol. 1967 Apr;93(4):1205–1209. doi: 10.1128/jb.93.4.1205-1209.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ebbesen P. Chronic respiratory disease in BALB-c mice. I. Pathology and relation to other murine lung infections. Am J Pathol. 1968 Aug;53(2):219–233. [PMC free article] [PubMed] [Google Scholar]
  11. FREEMAN G., HAYDON G. B. EMPHYSEMA AFTER LOW-LEVEL EXPOSURE TO NO2. Arch Environ Health. 1964 Jan;8:125–128. doi: 10.1080/00039896.1964.10663640. [DOI] [PubMed] [Google Scholar]
  12. Freeman G., Stephens R. J., Crane S. C., Furiosi N. J. Lesion of the lung in rats continuously exposed to two parts per million of nitrogen dioxide. Arch Environ Health. 1968 Aug;17(2):181–192. doi: 10.1080/00039896.1968.10665212. [DOI] [PubMed] [Google Scholar]
  13. GRAY J. E. NATURALLY OCCURRING AND SULFONAMIDE-INDUCED LESIONS IN RATS DURING A 1-YEAR TOXICITY STUDY. Am J Vet Res. 1963 Sep;24:1044–1059. [PubMed] [Google Scholar]
  14. GRICE H. C., GREGORY E. R., CONNELL M. R. Diagnosis of middle and inner ear disease in rats. J Am Vet Med Assoc. 1955 Nov;127(944):430–432. [PubMed] [Google Scholar]
  15. Ganaway J. R., Allen A. M. Chronic murine pneumonia of laboratory rats. Production and description of pulmonary-disease-free rats. Lab Anim Care. 1969 Feb;19(1):71–79. [PubMed] [Google Scholar]
  16. Gay F. W. Fine structure and location of the mycoplasma-like gray lung and rat pneumonia agents in infected mouse lung. J Bacteriol. 1967 Dec;94(6):2048–2061. doi: 10.1128/jb.94.6.2048-2061.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Giddens W. E., Jr, Whitehair C. K., Carter G. R. Morphologic and microbiologic features of nasal cavity and middle ear in germfree, defined-flora, conventional, and chronic respiratory disease-affected rats. Am J Vet Res. 1971 Jan;32(1):99–114. [PubMed] [Google Scholar]
  18. Giddens W. E., Jr, Whitehair C. K., Carter G. R. Morphologic and microbiologic features of trachea and lungs in germfree, defined-flora, conventional, and chronic respiratory disease-affected rats. Am J Vet Res. 1971 Jan;32(1):115–129. [PubMed] [Google Scholar]
  19. Gordon H. A., Bruckner-Kardoss E., Wostmann B. S. Aging in germ-free mice: life tables and lesions observed at natural death. J Gerontol. 1966 Jul;21(3):380–387. doi: 10.1093/geronj/21.3.380. [DOI] [PubMed] [Google Scholar]
  20. Greselin E. Detection of Otitis Media in the Rat. Can J Comp Med Vet Sci. 1961 Nov;25(11):274–276. [PMC free article] [PubMed] [Google Scholar]
  21. HABERMANN R. T., WILLIAMS F. P., Jr, McPHERSON C. W., EVERY R. R. The effect of orally administered sulfamerazine and chlortetracycline on chronic respiratory disease in rats. Lab Anim Care. 1963 Feb;13:28–40. [PubMed] [Google Scholar]
  22. HITCHCOCK C. R., BELL E. T. Studies on the nematode parasite, Gongylonema neoplasticum (spiroptera neoplasticum), and avitaminosis A in the forestomach of rats: comparison with Fibiger's results. J Natl Cancer Inst. 1952 Jun;12(6):1345–1387. [PubMed] [Google Scholar]
  23. HOWELL E. V., JONES R. S. Factors influencing pathogenicity of Mycoplasma arthritidis (PPLO). Proc Soc Exp Biol Med. 1963 Jan;112:69–72. doi: 10.3181/00379727-112-27952. [DOI] [PubMed] [Google Scholar]
  24. HOWELL E. V., WARD J. R., JONES R. S. Mycoplasmal (PPLO) polyarthritis and tumor regression in rats. Proc Soc Exp Biol Med. 1959 Oct;102:210–212. doi: 10.3181/00379727-102-25195. [DOI] [PubMed] [Google Scholar]
  25. Hayflick L. Tissue cultures and mycoplasmas. Tex Rep Biol Med. 1965 Jun;23(Suppl):285+–285+. [PubMed] [Google Scholar]
  26. INNES J. R., DONATI E. J., ROSS M. A., STOUFER R. M., YEVICH P. P., WILSON C. E., FARBER J. F., PANKEVICIUS J. A., DOWNING T. O. Establishment of a rat colony free from chronic murine pneumonia. Cornell Vet. 1957 Apr;47(2):260–280. [PubMed] [Google Scholar]
  27. INNES J. R., MCADAMS A. J., YEVICH P. Pulmonary disease in rats; a survey with comments on chronic murine pneumonia. Am J Pathol. 1956 Jan-Feb;32(1):141–159. [PMC free article] [PubMed] [Google Scholar]
  28. INNES J. R., STANTON M. F. Acute disease of the submaxillary and Harderian glands (sialo-dacryoadenitis) of rats with cytomegaly and no inclusion bodies. Am J Pathol. 1961 Apr;38:455–468. [PMC free article] [PubMed] [Google Scholar]
  29. Joshi N., Dale D. G., Blackwood A. C. Etiology of murine endemic pneumonia. Rev Can Biol. 1965 Sep;24(3):169–178. [PubMed] [Google Scholar]
  30. KIBLER H. H., SILSBY H. D., JOHNSON H. D. METABOLIC TRENDS AND LIFE SPAN OF RATS LIVING AT 9 C. AND 28 C. J Gerontol. 1963 Jul;18:235–239. doi: 10.1093/geronj/18.3.235. [DOI] [PubMed] [Google Scholar]
  31. KLIENEBERGER-NOBEL E., CHENG K. K. On the association of the pleuro-pneumonia-like L3 organism with experimentally produced bronchiectasis in rats. J Pathol Bacteriol. 1955 Jul;70(1):245–246. doi: 10.1002/path.1700700125. [DOI] [PubMed] [Google Scholar]
  32. Kilham L., Margolis G. Pathogenicity of minute virus of mice (MVM) for rats, mice, and hamsters. Proc Soc Exp Biol Med. 1970 Apr;133(4):1447–1452. doi: 10.3181/00379727-133-34710. [DOI] [PubMed] [Google Scholar]
  33. Kohn D. F., Kirk B. E. Pathogenicity of Mycoplasma pulmonis in laboratory rats. Lab Anim Care. 1969 Jun;19(3):321–330. [PubMed] [Google Scholar]
  34. Low I. E. Effect of Medium on H(2)O(2) Levels and Peroxidase-Like Activity by Mycoplasma pneumoniae. Infect Immun. 1971 Jan;3(1):80–86. doi: 10.1128/iai.3.1.80-86.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Lutsky I. I., Organick A. B. Pneumonia due to mycoplasma in gnotobiotic mice. I. Pathogenicity of Mycoplasma pneumoniae, Mycoplasma salivarium, and Mycoplasma pulmonis for the lungs of conventional and gnotobiotic mice. J Bacteriol. 1966 Oct;92(4):1154–1163. doi: 10.1128/jb.92.4.1154-1163.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. MOOSER H. Two varieties of murine PPLO strains distinguishable from each other by their mode of in vivo growth when associated with the virus of ectromelia. Arch Gesamte Virusforsch. 1951 Mar 30;4(3):207–216. doi: 10.1007/BF01255695. [DOI] [PubMed] [Google Scholar]
  37. Madden D. L., Horton R. E., McCullough N. B. Mycoplasma gallisepticum infection in germfree and conventional chickens: experimental studies with a culture of low virulence. Am J Vet Res. 1967 Mar;28(123):517–526. [PubMed] [Google Scholar]
  38. NELSON J. B. Studies on endemic pneumonia of the albino rat. IV. Development of a rat colony free from respiratory infections. J Exp Med. 1951 Nov;94(5):377–386. doi: 10.1084/jem.94.5.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. NELSON J. B. The enhancing effect of murine hepatitis virus on the cerebral activity of pleuropneumonia-like organisms in mice. J Exp Med. 1957 Aug 1;106(2):179–190. doi: 10.1084/jem.106.2.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. NEWBERNE P. M., SALMON W. D., HARE W. V. Chronic murine pneumonia in an experimental laboratory. Arch Pathol. 1961 Aug;72:224–233. [PubMed] [Google Scholar]
  41. Olson L. D., McCune E. L. Histopathology of chronic otitis media in the rat. Lab Anim Care. 1968 Aug;18(4):478–485. [PubMed] [Google Scholar]
  42. PANDOLA G. A., KREUTNER A., KREUTNER K., FARMER S. G. EXPERIMENTAL ASCENDING PYELONEPHRITIS IN RATS: EXPERIMENTAL HYDRONEPHROSIS WITH STERILE PYELONEPHRITIS. Lab Invest. 1964 Nov;13:1484–1489. [PubMed] [Google Scholar]
  43. PANKEVICIUS J. A., WILSON C. E., FARBER J. F. The debatable role of a pleuropneumonialike organism in the etiology of chronic pneumonia in rats. Cornell Vet. 1957 Apr;47(2):317–325. [PubMed] [Google Scholar]
  44. Parker J. C., Cross S. S., Rowe W. P. Rat coronavirus (RCV): a prevalent, naturally occurring pneumotropic virus of rats. Arch Gesamte Virusforsch. 1970;31(3):293–302. doi: 10.1007/BF01253764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Pollack J. D., Somerson N. L., Senterfit L. B. Effect of pH on the immunogenicity of Mycoplasma pneumoniae. J Bacteriol. 1969 Feb;97(2):612–619. doi: 10.1128/jb.97.2.612-619.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. REID L. AN EXPERIMENTAL STUDY OF HYPERSECRETION OF MUCUS IN THE BRONCHIAL TREE. Br J Exp Pathol. 1963 Aug;44:437–445. [PMC free article] [PubMed] [Google Scholar]
  47. REID L. NATURAL HISTORY OF MUCUS IN THE BRONCHIAL TREE. Arch Environ Health. 1965 Feb;10:265–273. doi: 10.1080/00039896.1965.10663994. [DOI] [PubMed] [Google Scholar]
  48. Ring R., Nelson J. D. Hydrocarbon pneumonitis in rats. Comparison of mineral seal oil furniture polish and kerosene toxicities with an evaluation of gastric lavage. Arch Environ Health. 1966 Dec;13(6):749–752. doi: 10.1080/00039896.1966.10664659. [DOI] [PubMed] [Google Scholar]
  49. SIMMS H. S., BERG B. N. Longevity and the onset of lesions in male rats. J Gerontol. 1957 Jul;12(3):244–252. doi: 10.1093/geronj/12.3.244. [DOI] [PubMed] [Google Scholar]
  50. Shorter R. G., Titus J. L., Divertie M. B. Cytodynamics in the respiratory tract of the rat. Thorax. 1966 Jan;21(1):32–37. doi: 10.1136/thx.21.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Spritzer A. A., Watson J. A., Auld J. A., Guetthoff M. A. Pulmonary macrophage clearance. The hourly rates of transfer of pulmonary macrophages to the oropharynx of the rat. Arch Environ Health. 1968 Nov;17(5):726–730. doi: 10.1080/00039896.1968.10665312. [DOI] [PubMed] [Google Scholar]
  52. Talbert G. B., Hamilton J. B. Duration of life in Lewis strain of rats after gonadectomy at birth and at older ages. J Gerontol. 1965 Oct;20(4):489–491. [PubMed] [Google Scholar]
  53. Tucker A. D., Wyatt J. H. Possible dietary factors in the aetiology of chronic murine pneumonia, nephrosis and peri-arteritis. Nature. 1967 Aug 26;215(5104):976–978. doi: 10.1038/215976a0. [DOI] [PubMed] [Google Scholar]
  54. VROLIJK H., VERLINDE J. D., BRAAMS W. G. Virus pneumonia (snuffling disease) in laboratory rats and wild rats due to an agent probably related to grey lung virus of mice. Antonie Van Leeuwenhoek. 1957;23(2):172–183. [PubMed] [Google Scholar]
  55. Ventura J., Domaradzki M. Pathogenesis of experimental bronchiectasis in laboratory rats. Arch Pathol. 1967 Jan;83(1):80–85. [PubMed] [Google Scholar]
  56. Wilens S. L., Sproul E. E. Spontaneous cardiovascular disease in the rat: I. Lesions of the heart. Am J Pathol. 1938 Mar;14(2):177–200.5. [PMC free article] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES