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. 1971 Sep;64(3):575–584.

Elevated Plasma Activity of Lactate Dehydrogenase Isoenzyme-3 (LDH3) in Experimentally Induced Immunologic Lung Injury

J E Hagadorn, C M Bloor, M S Yang
PMCID: PMC2047622  PMID: 5133518

Abstract

Normal rats injected intravenously with rabbit antiserum to rat lung develop acute pulmonary lesions characterized by an altered vascular permeability. In the present study, an increase in plasma LDH3 activity is shown to be positively correlated with the different levels of circulating antilung antibodies and with the morphologic severity of lung injury elicited by these pathogenic immunoglobulins. Within 24 hours, the acute lung changes are resolved, accompanied by a return of the activities of plasma LDH isoenzymes to normal. It is proposed that the plasma LDH3 isoenzymes are released into the circulation from injured alveolar capillary endothelial cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALTLAND P. D., HIGHMAN B. Effects of exercise on serum enzyme values and tissues of rats. Am J Physiol. 1961 Aug;201:393–395. doi: 10.1152/ajplegacy.1961.201.2.393. [DOI] [PubMed] [Google Scholar]
  2. Bloor C. M., Sobel B. E., Henry P. D. Autologous pulmonary embolism in the intact, unanesthetized dog. J Appl Physiol. 1970 Nov;29(5):670–674. doi: 10.1152/jappl.1970.29.5.670. [DOI] [PubMed] [Google Scholar]
  3. Emery A. E. The determination of lactate dehydrogenase isoenzymes in normal human muscle and other tissues. Biochem J. 1967 Nov;105(2):599–604. doi: 10.1042/bj1050599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hagadorn J. E., Vazquez J. J., Kinney T. R. Immunopathologic studies of an experimental model resembling Goodpasture's syndrome. Am J Pathol. 1969 Oct;57(1):17–30. [PMC free article] [PubMed] [Google Scholar]
  5. Papadopoulos N. M., Leon A. S., Bloor C. M. Effects of exercise on plasma and tissue levels of lactate dehydrogenase and isoenzymes in rats. Proc Soc Exp Biol Med. 1967 Jul;125(3):999–1002. doi: 10.3181/00379727-125-32260. [DOI] [PubMed] [Google Scholar]
  6. Schmidt D. M., Black M. B., Miller H., Jr, Chinn D. J. Modified microzone cellulose acetate method for lactic dehydrogenase isoenzymes--normal values. Am J Med Technol. 1969 Mar;35(3):153–157. [PubMed] [Google Scholar]
  7. TAMANOI I., YAGI Y., HIRAMOTO R., PRESSMAN D. Lung localizing antibodies in anti-lung and anti-kidney serum. Proc Soc Exp Biol Med. 1961 Mar;106:661–663. doi: 10.3181/00379727-106-26435. [DOI] [PubMed] [Google Scholar]
  8. Tsuzuku O., Yagi Y., Pressman D. Highly specific lung localizing antibodies. J Immunol. 1967 Jul;99(1):1–9. [PubMed] [Google Scholar]
  9. WROBLEWSKI F., LADUE J. S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med. 1955 Oct;90(1):210–213. doi: 10.3181/00379727-90-21985. [DOI] [PubMed] [Google Scholar]

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