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. 1994 Apr;176(8):2450–2453. doi: 10.1128/jb.176.8.2450-2453.1994

Plasmids of the pT181 family show replication-specific initiator protein modification.

A Rasooly 1, S J Projan 1, R P Novick 1
PMCID: PMC205372  PMID: 8157616

Abstract

The rolling circle plasmids of Staphylococcus aureus regulate their replication by controlling initiator (Rep) protein synthesis. It was demonstrated recently that the pT181 initiator protein RepC is inactivated during pT181 replication by the addition of an oligodeoxynucleotide, giving rise to a new form, RepC* (A. Rasooly and R. P. Novick, Science, 262:1048-1050). We establish here that this initiator modification occurs with four other members of the pT181 family and that it occurs in Bacillus subtilis as well as S. aureus. These results suggest that Rep conversion to Rep* is probably universal among plasmids of the pT181 family and is not host dependent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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