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. 1992 Jun;174(12):4042–4049. doi: 10.1128/jb.174.12.4042-4049.1992

Biosynthetic precursors of deazaflavins.

B Reuke 1, S Korn 1, W Eisenreich 1, A Bacher 1
PMCID: PMC206114  PMID: 1350778

Abstract

The incorporation of 13C- and 14C-labeled precursors into 5-deaza-7,8-didemethyl-8-hydroxyriboflavin (factor F0) was studied with growing cells of Methanobacterium thermoautotrophicum. 5-Amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione was incorporated into the deazaflavin and into riboflavin without dilution. Tyrosine and 4-hydroxyphenylpyruvate were incorporated into the deazaflavin and into cellular protein. 4-Hydroxybenzaldehyde was not incorporated. A reaction mechanism is proposed for the formation of the deazaflavin chromophore from 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione and tyrosine or 4-hydroxyphenylpyruvate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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