Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1998 Jul;78(1):125–128. doi: 10.1038/bjc.1998.453

Gastric cancer risk in relation to Helicobacter pylori infection and subtypes of intestinal metaplasia.

M S Wu 1, C T Shun 1, W C Lee 1, C J Chen 1, H P Wang 1, W J Lee 1, J T Lin 1
PMCID: PMC2062944  PMID: 9662262

Abstract

Helicobacter pylori (H. pylori) infection and intestinal metaplasia (IM) are each associated with an increased risk of gastric cancer (GC). To explore further the influences of H. pylori and IM on GC, H. pylori and subtypes of IM were evaluated in 135 sex and age-matched case and control pairs. Odds ratios (ORs) with 95% confidence intervals of developing GC were calculated for each risk factor using multiple logistic regression analysis. ORs for H. pylori infection and IM were 2.43 (1.29-4.65) and 4.59 (2.58-8.16), respectively, and those for different IM subtypes gave values of 0.82 (0.28-2.36) for type I, 2.03 (0.95-4.34) for type II and 39.75 (14.34-110.2) for type III. Stratification analysis by histological subtype and stage of GC showed a particularly high OR for IM in intestinal type (12.8, 4.73-34.83) and early GC (6.40, 2.25-18.18). Our data indicate that both H. pylori and IM are related to GC risk. Type III IM is a more specific marker of premalignancy, with relevance, in particular, to the early and intestinal type of GC.

Full text

PDF
125

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Antonioli D. A. Precursors of gastric carcinoma: a critical review with a brief description of early (curable) gastric cancer. Hum Pathol. 1994 Oct;25(10):994–1005. doi: 10.1016/0046-8177(94)90058-2. [DOI] [PubMed] [Google Scholar]
  2. Bechi P., Balzi M., Becciolini A., Maugeri A., Raggi C. C., Amorosi A., Dei R. Helicobacter pylori and cell proliferation of the gastric mucosa: possible implications for gastric carcinogenesis. Am J Gastroenterol. 1996 Feb;91(2):271–276. [PubMed] [Google Scholar]
  3. Caselli M. Helicobacter pylori, intestinal metaplasia, and gastric cancer: histopathological point of view. Am J Gastroenterol. 1996 Jul;91(7):1473–1475. [PubMed] [Google Scholar]
  4. Correa P., Fontham E., Pickle L. W., Chen V., Lin Y. P., Haenszel W. Dietary determinants of gastric cancer in south Louisiana inhabitants. J Natl Cancer Inst. 1985 Oct;75(4):645–654. [PubMed] [Google Scholar]
  5. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992 Dec 15;52(24):6735–6740. [PubMed] [Google Scholar]
  6. Crespi M., Citarda F. Helicobacter pylori and gastric cancer: an overrated risk? Scand J Gastroenterol. 1996 Nov;31(11):1041–1046. doi: 10.3109/00365529609036884. [DOI] [PubMed] [Google Scholar]
  7. Dobrilla G., Benvenuti S., Amplatz S., Zancanella L. Chronic gastritis, intestinal metaplasia, dysplasia and Helicobacter pylori in gastric cancer: putting the pieces together. Ital J Gastroenterol. 1994 Dec;26(9):449–458. [PubMed] [Google Scholar]
  8. Filipe M. I., Muñoz N., Matko I., Kato I., Pompe-Kirn V., Jutersek A., Teuchmann S., Benz M., Prijon T. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer. 1994 May 1;57(3):324–329. doi: 10.1002/ijc.2910570306. [DOI] [PubMed] [Google Scholar]
  9. Forman D., Newell D. G., Fullerton F., Yarnell J. W., Stacey A. R., Wald N., Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991 Jun 1;302(6788):1302–1305. doi: 10.1136/bmj.302.6788.1302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Forman D., Webb P., Parsonnet J. H pylori and gastric cancer. Lancet. 1994 Jan 22;343(8891):243–244. [PubMed] [Google Scholar]
  11. Jass J. R., Filipe M. I. A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study. Histopathology. 1979 May;3(3):191–199. doi: 10.1111/j.1365-2559.1979.tb02996.x. [DOI] [PubMed] [Google Scholar]
  12. LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. doi: 10.1111/apm.1965.64.1.31. [DOI] [PubMed] [Google Scholar]
  13. Lev R. The mucin histochemistry of normal and neoplastic gastric mucosa. Lab Invest. 1965 Dec;14(12):2080–2100. [PubMed] [Google Scholar]
  14. Lin J. T., Wang J. T., Wang T. H., Wu M. S., Lee T. K., Chen C. J. Helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. A seroprevalence study in Taiwan. Scand J Gastroenterol. 1993 Dec;28(12):1067–1072. doi: 10.3109/00365529309098311. [DOI] [PubMed] [Google Scholar]
  15. Masci E., Viale E., Freschi M., Porcellati M., Tittobello A. Precancerous gastric lesions and Helicobacter pylori. Hepatogastroenterology. 1996 Jul-Aug;43(10):854–858. [PubMed] [Google Scholar]
  16. Nomura A., Stemmermann G. N., Chyou P. H., Kato I., Perez-Perez G. I., Blaser M. J. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991 Oct 17;325(16):1132–1136. doi: 10.1056/NEJM199110173251604. [DOI] [PubMed] [Google Scholar]
  17. Parkin D. M., Pisani P., Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer. 1993 Jun 19;54(4):594–606. doi: 10.1002/ijc.2910540413. [DOI] [PubMed] [Google Scholar]
  18. Rubin C. E. Are there three types of Helicobacter pylori gastritis? Gastroenterology. 1997 Jun;112(6):2108–2110. doi: 10.1053/gast.1997.v112.agast972108. [DOI] [PubMed] [Google Scholar]
  19. Rugge M., Cassaro M., Leandro G., Baffa R., Avellini C., Bufo P., Stracca V., Battaglia G., Fabiano A., Guerini A. Helicobacter pylori in promotion of gastric carcinogenesis. Dig Dis Sci. 1996 May;41(5):950–955. doi: 10.1007/BF02091536. [DOI] [PubMed] [Google Scholar]
  20. Sipponen P., Kosunen T. U., Valle J., Riihelä M., Seppälä K. Helicobacter pylori infection and chronic gastritis in gastric cancer. J Clin Pathol. 1992 Apr;45(4):319–323. doi: 10.1136/jcp.45.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sobala G. M., Schorah C. J., Shires S., Lynch D. A., Gallacher B., Dixon M. F., Axon A. T. Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations. Gut. 1993 Aug;34(8):1038–1041. doi: 10.1136/gut.34.8.1038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Solcia E., Fiocca R., Luinetti O., Villani L., Padovan L., Calistri D., Ranzani G. N., Chiaravalli A., Capella C. Intestinal and diffuse gastric cancers arise in a different background of Helicobacter pylori gastritis through different gene involvement. Am J Surg Pathol. 1996;20 (Suppl 1):S8–22. doi: 10.1097/00000478-199600001-00003. [DOI] [PubMed] [Google Scholar]
  23. Stemmermann G. N. Intestinal metaplasia of the stomach. A status report. Cancer. 1994 Jul 15;74(2):556–564. doi: 10.1002/1097-0142(19940715)74:2<556::aid-cncr2820740205>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  24. Stemmermann G. N., Nomura A. M., Chyou P. H., Hankin J. Impact of diet and smoking on risk of developing intestinal metaplasia of the stomach. Dig Dis Sci. 1990 Apr;35(4):433–438. doi: 10.1007/BF01536915. [DOI] [PubMed] [Google Scholar]
  25. Turani H., Lurie B., Chaimoff C., Kessler E. The diagnostic significance of sulfated acid mucin content in gastric intestinal metaplasia with early gastric cancer. Am J Gastroenterol. 1986 May;81(5):343–345. [PubMed] [Google Scholar]
  26. Wu M. S., Lin J. T., Lee W. J., Yu S. C., Wang T. H. [Gastric cancer in Taiwan]. J Formos Med Assoc. 1994 Sep;93 (Suppl 2):S77–S89. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES