Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1998 Jul;78(1):46–49. doi: 10.1038/bjc.1998.440

Is prostatic intraepithelial neoplasia in the transition/central zone a true precursor of cancer? A long-term retrospective study in Norway.

S Harvei 1, F J Skjørten 1, T E Robsahm 1, A Berner 1, S Tretli 1
PMCID: PMC2062946  PMID: 9662249

Abstract

Prostatic intraepithelial neoplasia (PIN) has been considered as a precursor of prostatic cancer. Few reports have dealt with the long-term follow-up of PIN lesions, and there is still a lack of proof that PIN is a true premalignant lesion. The objective of this study was to evaluate PIN in the transition/central zone as a marker for subsequent development of prostatic cancer. The PIN status of tissue specimens from 789 men without prostate cancer was determined in 508 transurethral resections and 281 transvesical prostatic enucleations. All slides were reviewed blind and independently by two pathologists. The patients were followed for an average of 11 years, and the incidence of subsequent cancer and cause-specific survival were analysed. Thirty-six cases of clinical prostatic cancer occurred among the cohort of 789 men through follow-up. No association between the presence of PIN in the transition/central zone and subsequent cancer development was found. There was also no difference in survival related to PIN status among the subsequent cancer patients.

Full text

PDF
46

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aboseif S., Shinohara K., Weidner N., Narayan P., Carroll P. R. The significance of prostatic intra-epithelial neoplasia. Br J Urol. 1995 Sep;76(3):355–359. doi: 10.1111/j.1464-410x.1995.tb07714.x. [DOI] [PubMed] [Google Scholar]
  2. Allam C. K., Bostwick D. G., Hayes J. A., Upton M. P., Wade G. G., Domanowski G. F., Klein M. A., Boling E. A., Stilmant M. M. Interobserver variability in the diagnosis of high-grade prostatic intraepithelial neoplasia and adenocarcinoma. Mod Pathol. 1996 Jul;9(7):742–751. [PubMed] [Google Scholar]
  3. Babaian R. J., Troncoso P., Ayala A. Transurethral-resection zone prostate cancer detected at cystoprostatectomy. A detailed histologic analysis and clinical implications. Cancer. 1991 Mar 1;67(5):1418–1422. doi: 10.1002/1097-0142(19910301)67:5<1418::aid-cncr2820670524>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  4. Berner A., Danielsen H. E., Pettersen E. O., Fosså S. D., Reith A., Nesland J. M. DNA distribution in the prostate. Normal gland, benign and premalignant lesions, and subsequent adenocarcinomas. Anal Quant Cytol Histol. 1993 Aug;15(4):247–252. [PubMed] [Google Scholar]
  5. Berner A., Skjørten F. J., Fossà S. D. Follow-up of prostatic intraepithelial neoplasia. Eur Urol. 1996;30(2):256–260. doi: 10.1159/000474177. [DOI] [PubMed] [Google Scholar]
  6. Bostwick D. G., Algaba F., Amin M. B., Ayala A., Eble J., Goldstein N., Helpap B., Humphrey P., Grignon D., Jones E. C. Consensus statement on terminology: recommendation to use atypical adenomatous hyperplasia in place of adenosis of the prostate. Am J Surg Pathol. 1994 Oct;18(10):1069–1070. [PubMed] [Google Scholar]
  7. Bostwick D. G., Brawer M. K. Prostatic intra-epithelial neoplasia and early invasion in prostate cancer. Cancer. 1987 Feb 15;59(4):788–794. doi: 10.1002/1097-0142(19870215)59:4<788::aid-cncr2820590421>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  8. Bostwick D. G., Pacelli A., Lopez-Beltran A. Molecular biology of prostatic intraepithelial neoplasia. Prostate. 1996 Aug;29(2):117–134. doi: 10.1002/(SICI)1097-0045(199608)29:2<117::AID-PROS7>3.0.CO;2-C. [DOI] [PubMed] [Google Scholar]
  9. Brawer M. K. Prostatic intraepithelial neoplasia: a premalignant lesion. J Cell Biochem Suppl. 1992;16G:171–174. doi: 10.1002/jcb.240501129. [DOI] [PubMed] [Google Scholar]
  10. Brawer M. K. Prostatic intraepithelial neoplasia: a premalignant lesion. Hum Pathol. 1992 Mar;23(3):242–248. doi: 10.1016/0046-8177(92)90104-b. [DOI] [PubMed] [Google Scholar]
  11. Davidson D., Bostwick D. G., Qian J., Wollan P. C., Oesterling J. E., Rudders R. A., Siroky M., Stilmant M. Prostatic intraepithelial neoplasia is a risk factor for adenocarcinoma: predictive accuracy in needle biopsies. J Urol. 1995 Oct;154(4):1295–1299. [PubMed] [Google Scholar]
  12. Epstein J. I., Cho K. R., Quinn B. D. Relationship of severe dysplasia to stage A (incidental) adenocarcinoma of the prostate. Cancer. 1990 May 15;65(10):2321–2327. doi: 10.1002/1097-0142(19900515)65:10<2321::aid-cncr2820651026>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  13. Garborg I., Eide T. J. The probability of overlooking prostatic cancer in transurethrally resected material when different embedding practices are followed. Acta Pathol Microbiol Immunol Scand A. 1985 Sep;93(5):205–208. doi: 10.1111/j.1699-0463.1985.tb03942.x. [DOI] [PubMed] [Google Scholar]
  14. Garnett J. E., Oyasu R. Urologic evaluation of atypical prostatic hyperplasia. Urology. 1989 Dec;34(6 Suppl):66–69. [PubMed] [Google Scholar]
  15. Harvei S., Tretli S., Langmark F. Quality of prostate cancer data in the cancer registry of Norway. Eur J Cancer. 1996 Jan;32A(1):104–110. doi: 10.1016/0959-8049(95)00501-3. [DOI] [PubMed] [Google Scholar]
  16. Häggman M. J., Macoska J. A., Wojno K. J., Oesterling J. E. The relationship between prostatic intraepithelial neoplasia and prostate cancer: critical issues. J Urol. 1997 Jul;158(1):12–22. doi: 10.1097/00005392-199707000-00004. [DOI] [PubMed] [Google Scholar]
  17. McNeal J. E., Redwine E. A., Freiha F. S., Stamey T. A. Zonal distribution of prostatic adenocarcinoma. Correlation with histologic pattern and direction of spread. Am J Surg Pathol. 1988 Dec;12(12):897–906. doi: 10.1097/00000478-198812000-00001. [DOI] [PubMed] [Google Scholar]
  18. Montironi R., Bostwick D. G., Bonkhoff H., Cockett A. T., Helpap B., Troncoso P., Waters D. Origins of prostate cancer. Cancer. 1996 Jul 15;78(2):362–365. doi: 10.1002/(SICI)1097-0142(19960715)78:2<362::AID-CNCR28>3.0.CO;2-T. [DOI] [PubMed] [Google Scholar]
  19. Qian J., Bostwick D. G. The extent and zonal location of prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia: relationship with carcinoma in radical prostatectomy specimens. Pathol Res Pract. 1995 Sep;191(9):860–867. doi: 10.1016/S0344-0338(11)80969-6. [DOI] [PubMed] [Google Scholar]
  20. Qian J., Wollan P., Bostwick D. G. The extent and multicentricity of high-grade prostatic intraepithelial neoplasia in clinically localized prostatic adenocarcinoma. Hum Pathol. 1997 Feb;28(2):143–148. doi: 10.1016/s0046-8177(97)90097-6. [DOI] [PubMed] [Google Scholar]
  21. Sakr W. A., Grignon D. J., Crissman J. D., Heilbrun L. K., Cassin B. J., Pontes J. J., Haas G. P. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases. In Vivo. 1994 May-Jun;8(3):439–443. [PubMed] [Google Scholar]
  22. Skjørten F. J., Berner A., Harvei S., Robsahm T. E., Tretli S. Prostatic intraepithelial neoplasia in surgical resections: relationship to coexistent adenocarcinoma and atypical adenomatous hyperplasia of the prostate. Cancer. 1997 Mar 15;79(6):1172–1179. doi: 10.1002/(sici)1097-0142(19970315)79:6<1172::aid-cncr16>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  23. Stone E. Prostatic intraepithelial neoplasia: will it help doctors pinpoint early prostate cancer? J Natl Cancer Inst. 1996 Aug 7;88(15):1023–1024. doi: 10.1093/jnci/88.15.1023. [DOI] [PubMed] [Google Scholar]
  24. Weinstein M. H., Epstein J. I. Significance of high-grade prostatic intraepithelial neoplasia on needle biopsy. Hum Pathol. 1993 Jun;24(6):624–629. doi: 10.1016/0046-8177(93)90242-9. [DOI] [PubMed] [Google Scholar]
  25. de la Torre M., Häggman M., Brändstedt S., Busch C. Prostatic intraepithelial neoplasia and invasive carcinoma in total prostatectomy specimens: distribution, volumes and DNA ploidy. Br J Urol. 1993 Aug;72(2):207–213. doi: 10.1111/j.1464-410x.1993.tb00689.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES