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. 1998 Sep;78(5):561–565. doi: 10.1038/bjc.1998.540

Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.

G M Taylor 1, S Dearden 1, N Payne 1, M Ayres 1, D A Gokhale 1, J M Birch 1, V Blair 1, R F Stevens 1, A M Will 1, O B Eden 1
PMCID: PMC2063058  PMID: 9744491

Abstract

Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.

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Selected References

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