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. 1997;75(3):441–444. doi: 10.1038/bjc.1997.73

Body mass index and post-menopausal breast cancer: an age-specific analysis.

C La Vecchia 1, E Negri 1, S Franceschi 1, R Talamini 1, P Bruzzi 1, D Palli 1, A Decarli 1
PMCID: PMC2063359  PMID: 9020494

Abstract

The relationship between body mass index (BMI, Quetelet's index, kg m(-2)) and post-menopausal breast cancer risk was considered in age-specific strata on the basis of a pooled analysis of three Italian case-control studies, including a total of 3108 post-menopausal breast cancer patients aged 50 years or over and 2664 control subjects. Overall, there was a moderate, but significant, association between BMI and post-menopausal breast cancer: the odds ratios (ORs) were around 1.3 for the three intermediate quintiles compared with the lowest one, and 1.4 for the highest one. The association was moderate among women aged 50-59 years and 60-69 years, with ORs around 1.3 for the highest BMI quintiles, but stronger among elderly women, with ORs of 1.6 for the fourth and 2.1 for the fifth quintile. An 8-unit increase in BMI involved an OR of 1.18 at age 50-59 years, of 1.14 at age 60-69 years and of 1.59 above age 70 years. This pattern of risk is similar to that observed for post-menopausal hormone replacement treatment and is consistent with a duration-risk relationship in the exposure to high oestrogen levels and with a greater differential in oestrogen levels in overweight elderly women. In terms of population attributable risk, 19.6% of all post-menopausal breast cancer patients and 27.1% of those in women above age 70 years were attributable to overweight and obesity in this population. This has, therefore, major preventive implications as to reduce breast cancer risk late in life, it is essentially important to control weight gain in elderly women.

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Selected References

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  1. Ballard-Barbash R., Schatzkin A., Taylor P. R., Kahle L. L. Association of change in body mass with breast cancer. Cancer Res. 1990 Apr 1;50(7):2152–2155. [PubMed] [Google Scholar]
  2. Barnes-Josiah D., Potter J. D., Sellers T. A., Himes J. H. Early body size and subsequent weight gain as predictors of breast cancer incidence (Iowa, United States). Cancer Causes Control. 1995 Mar;6(2):112–118. doi: 10.1007/BF00052771. [DOI] [PubMed] [Google Scholar]
  3. Brinton L. A., Swanson C. A. Height and weight at various ages and risk of breast cancer. Ann Epidemiol. 1992 Sep;2(5):597–609. doi: 10.1016/1047-2797(92)90004-a. [DOI] [PubMed] [Google Scholar]
  4. Bruzzi P., Green S. B., Byar D. P., Brinton L. A., Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol. 1985 Nov;122(5):904–914. doi: 10.1093/oxfordjournals.aje.a114174. [DOI] [PubMed] [Google Scholar]
  5. Colditz G. A., Hankinson S. E., Hunter D. J., Willett W. C., Manson J. E., Stampfer M. J., Hennekens C., Rosner B., Speizer F. E. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med. 1995 Jun 15;332(24):1589–1593. doi: 10.1056/NEJM199506153322401. [DOI] [PubMed] [Google Scholar]
  6. Day N. E., Brown C. C. Multistage models and primary prevention of cancer. J Natl Cancer Inst. 1980 Apr;64(4):977–989. [PubMed] [Google Scholar]
  7. Franceschi S., Favero A., La Vecchia C., Barón A. E., Negri E., Dal Maso L., Giacosa A., Montella M., Conti E., Amadori D. Body size indices and breast cancer risk before and after menopause. Int J Cancer. 1996 Jul 17;67(2):181–186. doi: 10.1002/(SICI)1097-0215(19960717)67:2<181::AID-IJC5>3.0.CO;2-P. [DOI] [PubMed] [Google Scholar]
  8. Hsieh C. C., Trichopoulos D., Katsouyanni K., Yuasa S. Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: associations and interactions in an international case-control study. Int J Cancer. 1990 Nov 15;46(5):796–800. doi: 10.1002/ijc.2910460508. [DOI] [PubMed] [Google Scholar]
  9. Hunter D. J., Willett W. C. Diet, body size, and breast cancer. Epidemiol Rev. 1993;15(1):110–132. doi: 10.1093/oxfordjournals.epirev.a036096. [DOI] [PubMed] [Google Scholar]
  10. La Vecchia C., Negri E., Franceschi S., Favero A., Nanni O., Filiberti R., Conti E., Montella M., Veronesi A., Ferraroni M. Hormone replacement treatment and breast cancer risk: a cooperative Italian study. Br J Cancer. 1995 Jul;72(1):244–248. doi: 10.1038/bjc.1995.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. La Vecchia C. Oestrogens and progestins and breast cancer risk in post-menopausal women. Pharmacol Res. 1995 Dec;32(6):323–324. doi: 10.1016/s1043-6618(05)80033-7. [DOI] [PubMed] [Google Scholar]
  12. Lubin F., Ruder A. M., Wax Y., Modan B. Overweight and changes in weight throughout adult life in breast cancer etiology. A case-control study. Am J Epidemiol. 1985 Oct;122(4):579–588. doi: 10.1093/oxfordjournals.aje.a114137. [DOI] [PubMed] [Google Scholar]
  13. Mezzetti M., Ferraroni M., Decarli A., La Vecchia C., Benichou J. Software for attributable risk and confidence interval estimation in case-control studies. Comput Biomed Res. 1996 Feb;29(1):63–75. doi: 10.1006/cbmr.1996.0006. [DOI] [PubMed] [Google Scholar]
  14. Negri E., La Vecchia C., Bruzzi P., Dardanoni G., Decarli A., Palli D., Parazzini F., Rosselli del Turco M. Risk factors for breast cancer: pooled results from three Italian case-control studies. Am J Epidemiol. 1988 Dec;128(6):1207–1215. doi: 10.1093/oxfordjournals.aje.a115075. [DOI] [PubMed] [Google Scholar]
  15. Negri E., Pagano R., Decarli A., La Vecchia C. Body weight and the prevalence of chronic diseases. J Epidemiol Community Health. 1988 Mar;42(1):24–29. doi: 10.1136/jech.42.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pike M. C. Age-related factors in cancers of the breast, ovary, and endometrium. J Chronic Dis. 1987;40 (Suppl 2):59S–69S. doi: 10.1016/s0021-9681(87)80009-7. [DOI] [PubMed] [Google Scholar]
  17. Pike M. C., Krailo M. D., Henderson B. E., Casagrande J. T., Hoel D. G. 'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer. Nature. 1983 Jun 30;303(5920):767–770. doi: 10.1038/303767a0. [DOI] [PubMed] [Google Scholar]
  18. Stoll B. A. Breast cancer: the obesity connection. Br J Cancer. 1994 May;69(5):799–801. doi: 10.1038/bjc.1994.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Talamini R., La Vecchia C., Franceschi S., Colombo F., Decarli A., Grattoni E., Grigoletto E., Tognoni G. Reproductive and hormonal factors and breast cancer in a Northern Italian population. Int J Epidemiol. 1985 Mar;14(1):70–74. doi: 10.1093/ije/14.1.70. [DOI] [PubMed] [Google Scholar]
  20. Tavani A., Negri E., Franceschi S., Parazzini F., La Vecchia C. Oral contraceptives and breast cancer in northern Italy. Final report from a case-control study. Br J Cancer. 1993 Sep;68(3):568–571. doi: 10.1038/bjc.1993.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Toti A., Agugiaro S., Amadori D., Buzzi G., Bruzzi P., Buiatti E., Capelli M. C., Ciatto S., Delfino E., Foti E. Breast cancer risk factors in Italian women: a multicentric case-control study. Tumori. 1986 Jun 30;72(3):241–249. doi: 10.1177/030089168607200304. [DOI] [PubMed] [Google Scholar]
  22. Ursin G., Longnecker M. P., Haile R. W., Greenland S. A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology. 1995 Mar;6(2):137–141. doi: 10.1097/00001648-199503000-00009. [DOI] [PubMed] [Google Scholar]

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