Figure 1.

T-cell activation status influences establishment of active, preintegration- or postintegration latency. (A) HIV infection of unactivated, resting T-cells results in labile preintegration latency with unintegrated, cytoplasmasmic provirus. (B) Infection of activated T-cells results in integrated provirus and active infection with efficient production of progeny virions. (C) Infection of cells in the process of resolving T-cell activation permits completion of reverse transcription and integration, but fails to support active expression of viral genes, i.e. postintegration latency.