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. 1982 May;76(1):185–194. doi: 10.1111/j.1476-5381.1982.tb09205.x

Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat.

G J Blackwell, R Carnuccio, M Di Rosa, R J Flower, C S Langham, L Parente, P Persico, N C Russel-Smith, D Stone
PMCID: PMC2068758  PMID: 6282373

Abstract

1 Dexamethasone and hydrocortisone induced the release of anti-phospholipase proteins into the peritoneal cavities of rats. 2 Adrenocorticotrophic hormone (ACTH) also releases these proteins in normal but not in adrenalectomized rats. 3 Peritoneal lavage proteins were separated by ion-exchange and size exclusion chromatography. The anti-phospholipase activity occurred in four separate fractions with the major component having an apparent mol. wt. of 40 k. 4 Column fractions containing these anti-phospholipase proteins had anti-inflammatory effects in the rat carrageenin pleurisy model whereas other fractions were inactive. 5 The proteins appear to be identical to macrocortin and lipomodulin, the 'second messengers' of glucocorticoid hormone action on the arachidonate system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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