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. 1982 May;76(1):51–59. doi: 10.1111/j.1476-5381.1982.tb09190.x

Increased histamine-output from the isolated gastric mucosa of the rat in response to pentagastrin and methacholine.

I H Main, J B Pearce
PMCID: PMC2068765  PMID: 6177370

Abstract

1 A rat isolated gastric mucosal preparation was used to monitor histamine output and acid secretion during stimulation by different secretagogues. 2 In non-stimulated preparations, spontaneous histamine output decreased over 450 min. 3 Stimulation of secretion with 4 (5)-methylhistamine or dibutyryl cyclic adenosine 3'5'-monophosphate (db cyclic AMP) and theophylline did not influence histamine output. 4 Pentagastrin, gastrin and methacholine increased both acid secretion and histamine output. Pentagastrin and gastrin mobilized six times more histamine and relation to acid secretion than did methacholine. 5 Spontaneous histamine output and secretagogue-induced increases were unaffected by changes in external Ca2+ (0.0 to 7.2 mM) or Mg2+ (1.2 to 4.8 mM). 6 These results support the hypothesis that mucosal histamine plays a more important role in the action of gastrin than of cholinomimetics on the parietal cell.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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