Abstract
1 The effect of intracerebroventricular (i.c.v.) injection of histamine on the rectal temperature of Mastomys natalensis at ambient temperatures of 10, 24 and 33 degrees C has been studied. 2 Low doses (0.1-1.0 microgram) of histamine produced hypothermia while larger doses (5-20 micrograms) produced dose-dependent hyperthermia. The hypothermic effect was significantly antagonized by mepyramine while the hyperthermia was blocked by cimetidine. 3 Histamine H1-receptor agonists, 2-methyl-histamine and 2-pyridyl-ethylamine, also produced hypothermia which could be blocked by mepyramine. 4 Histamine H2-receptor agonists, impromidine and dimaprit, produced hyperthermia which was antagonized by cimetidine. 5 Pretreatment of the animals with a beta-adrenoceptor antagonist, MJ1999, did not affect the response to histamine. 6 The hyperthermic effect of histamine (10 micrograms) was most marked at 10 degrees C and was attenuated at 33 degrees C. 7 It is concluded that both H1 and H2-histamine receptors are present in the brain of Mastomys. The H1-receptors mediate hypothermia and H2-receptors hyperthermia.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ash A. S., Schild H. O. Receptors mediating some actions of histamine. Br J Pharmacol Chemother. 1966 Aug;27(2):427–439. doi: 10.1111/j.1476-5381.1966.tb01674.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Black J. W., Duncan W. A., Durant C. J., Ganellin C. R., Parsons E. M. Definition and antagonism of histamine H 2 -receptors. Nature. 1972 Apr 21;236(5347):385–390. doi: 10.1038/236385a0. [DOI] [PubMed] [Google Scholar]
- Brezenoff H. E., Lomax P. Temperature changes following microinjection of histamine into the thermoregulatory centers of the rat. Experientia. 1970 Jan 15;26(1):51–52. doi: 10.1007/BF01900386. [DOI] [PubMed] [Google Scholar]
- Burn J. H., Dale H. H. The vaso-dilator action of histamine, and its physiological significance. J Physiol. 1926 Apr 23;61(2):185–214. doi: 10.1113/jphysiol.1926.sp002283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Durant G. J., Duncan W. A., Ganellin C. R., Parsons M. E., Blakemore R. C., Rasmussen A. C. Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors. Nature. 1978 Nov 23;276(5686):403–405. doi: 10.1038/276403a0. [DOI] [PubMed] [Google Scholar]
- Durant G. J., Ganellin C. R., Parsons M. E. Chemical differentiation of histamine H1- and H2-receptor agonists. J Med Chem. 1975 Sep;18(9):905–909. doi: 10.1021/jm00243a009. [DOI] [PubMed] [Google Scholar]
- Finch L., Hicks P. E. The cardiovascular effects of intraventricularly administered histamine in the anaesthetised rat. Naunyn Schmiedebergs Arch Pharmacol. 1976 May;293(2):151–157. doi: 10.1007/BF00499220. [DOI] [PubMed] [Google Scholar]
- Green M. D., Cox B., Lomax P. Histamine H1- and H2-receptors in the central thermoregulatory pathways of the rat. J Neurosci Res. 1975;1(5-6):353–359. doi: 10.1002/jnr.490010504. [DOI] [PubMed] [Google Scholar]
- HALL C. H., Jr, ATKINS E. Studies on tuberculin fever. I. The mechanism of fever in tuberculin hypersensitivity. J Exp Med. 1959 Apr 1;109(4):339–359. doi: 10.1084/jem.109.4.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shaw G. G. Hypothermia produced in mice by histamine acting on the central nervous system. Br J Pharmacol. 1971 Jun;42(2):205–214. doi: 10.1111/j.1476-5381.1971.tb07101.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shukla R., Srimal R. C., Dhawan B. N. A technique for chronic cannulation of the lateral cerebral ventricle in Mastomys natalensis. Indian J Exp Biol. 1981 Jan;19(1):97–98. [PubMed] [Google Scholar]