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. 1981 Feb;72(2):285–289. doi: 10.1111/j.1476-5381.1981.tb09127.x

The effects of amiloride and triamterene on urinary magnesium excretion in conscious saline-loaded rats.

J Devane, M P Ryan
PMCID: PMC2071520  PMID: 7214099

Abstract

1 The potassium-sparing diuretics, triamterene and amiloride, reduced urinary magnesium excretion in conscious saline-loaded rats. 2 Urinary magnesium-conservation was also detected when amiloride was used in combination with the potent 'loop-blocking' diuretic, frusemide.

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Selected References

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  1. Alfredson K. S., Walser M. Is magnesium secreted by the rat renal tubule? Nephron. 1970;7(3):241–247. doi: 10.1159/000179826. [DOI] [PubMed] [Google Scholar]
  2. Averill C. M., Heaton F. W. The renal handling of magnesium. Clin Sci. 1966 Dec;31(3):353–360. [PubMed] [Google Scholar]
  3. Brunette M. G., Vigneault N., Carriere S. Micropuncture study of magnesium transport along the nephron in the young rat. Am J Physiol. 1974 Oct;227(4):891–896. doi: 10.1152/ajplegacy.1974.227.4.891. [DOI] [PubMed] [Google Scholar]
  4. Duarte C. G., Chomety F., Giebisch G. Effect of amiloride, ouabain, and furosemide on distal tubular function in the rat. Am J Physiol. 1971 Aug;221(2):632–640. doi: 10.1152/ajplegacy.1971.221.2.632. [DOI] [PubMed] [Google Scholar]
  5. Duarte C. G. Effects of ethacrynic acid and furosemide on urinary calcium, phosphate and magnesium. Metabolism. 1968 Oct;17(10):867–876. doi: 10.1016/0026-0495(68)90151-0. [DOI] [PubMed] [Google Scholar]
  6. HORTON R., BIGLIERI E. G. Effect of aldosterone on the metabolism of magnesium. J Clin Endocrinol Metab. 1962 Dec;22:1187–1192. doi: 10.1210/jcem-22-12-1187. [DOI] [PubMed] [Google Scholar]
  7. Hänze S., Seyberth H. Untersuchungen zur Wirkung der Diuretica Furosemid, Etacrynsäure und Triamteren auf die renale Magnesium- und Calciumaussecheidung. Klin Wochenschr. 1967 Mar 15;45(6):313–314. doi: 10.1007/BF01747104. [DOI] [PubMed] [Google Scholar]
  8. Lim P., Jacob E. Magnesium-saving property of an aldosterone antagonist in the treatment of oedema of liver cirrhosis. Br Med J. 1978 Mar 25;1(6115):755–756. doi: 10.1136/bmj.1.6115.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Massry S. G., Coburn J. W., Kleeman C. R. Renal handling of magnesium in the dog. Am J Physiol. 1969 Jun;216(6):1460–1467. doi: 10.1152/ajplegacy.1969.216.6.1460. [DOI] [PubMed] [Google Scholar]
  10. Ryan M. P., Hingerty D. Effects of magnesium deficiency on restoration of potassium and sodium levels in potassium-depleted muscle. Ir J Med Sci. 1969 Mar;8(3):137–140. doi: 10.1007/BF02958922. [DOI] [PubMed] [Google Scholar]
  11. Sachtjen E., Meyer W. A., Massry S. G. Evidence of magnesium secretion during phosphate depletion in the rat. Proc Soc Exp Biol Med. 1979 Dec;162(3):416–419. doi: 10.3181/00379727-162-40694. [DOI] [PubMed] [Google Scholar]
  12. Seely J. F., Dirks J. H. Site of action of diuretic drugs. Kidney Int. 1977 Jan;11(1):1–8. doi: 10.1038/ki.1977.1. [DOI] [PubMed] [Google Scholar]
  13. WHANG R., WELT L. G. Observations in experimental magnesium depletion. J Clin Invest. 1963 Mar;42:305–313. doi: 10.1172/JCI104717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wen S. F., Evanson R. L., Dirks J. H. Micropuncture study of renal magnesium transport in proximal and distal tubule of the dog. Am J Physiol. 1970 Sep;219(3):570–576. doi: 10.1152/ajplegacy.1970.219.3.570. [DOI] [PubMed] [Google Scholar]
  15. Wen S. F., Wong N. L., Dirks J. H. Evidence for renal magnesium secretion during magnesium infusions in the dog. Am J Physiol. 1971 Jan;220(1):33–37. doi: 10.1152/ajplegacy.1971.220.1.33. [DOI] [PubMed] [Google Scholar]
  16. Whang R., Aikawa J. K. Magnesium deficiency and refractioriness to potassium repletion. J Chronic Dis. 1977 Feb;30(2):65–68. doi: 10.1016/0021-9681(77)90075-3. [DOI] [PubMed] [Google Scholar]
  17. Wiebelhaus V. D., Weinstock J., Maass A. B., Brennan F. T., Sosnowski G., Larsen T. The diuretic and natruretic activity of triamterene and several related pteridines in the rat. J Pharmacol Exp Ther. 1965 Sep;149(3):397–403. [PubMed] [Google Scholar]

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