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. 1981 Feb;72(2):257–262. doi: 10.1111/j.1476-5381.1981.tb09122.x

Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus.

J Arendt, A K Ho, C Laud, A Marston, V Nohria, J A Smith, A M Symons
PMCID: PMC2071522  PMID: 7214095

Abstract

1 Low doses (50 and 80 mg/kg) of benserazide (Ro4-4602), an aromatic amino acid decarboxylase inhibitor, markedly reduced 5-hydroxytryptamine and melatonin in the rat pineal gland without affecting hypothalamic 5-hydroxytryptamine. 2 This differential effect shows that inhibition of the pineal gland decarboxylase activity is possible, and confirms that the rat pineal gland is accessible to peripherally acting agents.

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Selected References

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