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. 1981 Jan;72(1):13–15. doi: 10.1111/j.1476-5381.1981.tb09098.x

Unexpected antagonism in the rat vas deferens by benzomorphans which are agonists in other pharmacological tests

Maureen GC Gillan, Hans W Kosterlitz, Jacques Magnan
PMCID: PMC2071548  PMID: 6261863

Abstract

The benzomorphans, ethylketazocine, bremazocine and MR 2034 are pure agonists in the guinea-pig ileum and mouse vas deferens but are competitive antagonists without agonist activity in the rat vas deferens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARUNLAKSHANA O., SCHILD H. O. Some quantitative uses of drug antagonists. Br J Pharmacol Chemother. 1959 Mar;14(1):48–58. doi: 10.1111/j.1476-5381.1959.tb00928.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gilbert P. E., Martin W. R. The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. J Pharmacol Exp Ther. 1976 Jul;198(1):66–82. [PubMed] [Google Scholar]
  3. Hutchinson M., Kosterlitz H. W., Leslie F. M., Waterfield A. A. Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey. Br J Pharmacol. 1975 Dec;55(4):541–546. doi: 10.1111/j.1476-5381.1975.tb07430.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kosterlitz H. W., Paterson S. J. Characterization of opioid receptors in nervous tissue. Proc R Soc Lond B Biol Sci. 1980 Oct 29;210(1178):113–122. doi: 10.1098/rspb.1980.0122. [DOI] [PubMed] [Google Scholar]
  5. Lemaire S., Magnan J., Regoli D. Rat vas deferens: a specific bioassay for endogenous opioid peptides. Br J Pharmacol. 1978 Nov;64(3):327–329. doi: 10.1111/j.1476-5381.1978.tb08653.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Martin W. R., Eades C. G., Thompson J. A., Huppler R. E., Gilbert P. E. The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther. 1976 Jun;197(3):517–532. [PubMed] [Google Scholar]
  7. Schulz R., Faase E., Wüster M., Herz A. Selective receptors for beta-endorphin on the rat vas deferens. Life Sci. 1979 Feb 26;24(9):843–849. doi: 10.1016/0024-3205(79)90368-0. [DOI] [PubMed] [Google Scholar]

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