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. 1981 Jan;72(1):81–88. doi: 10.1111/j.1476-5381.1981.tb09108.x

The anticoagulant activity of dermatan sulphates: evidence against the involvement of antithrombin III.

G Kindness, W F Long, F B Williamson
PMCID: PMC2071556  PMID: 7225714

Abstract

Anticoagulant activity of dermatan sulphates is unaffected by antiserum specific for antithrombin III (AT III) unless the glycosaminoglycan preparation contains demonstrable heparin. 2 Only dermatan sulphate preparations of considerable heparin content potentiate AT III inhibition of thrombin, factor Xa and plasmin. 3 These data suggest that dermatan sulphates exert anticoagulant activity which, unlike that of heparin, is largely or totally independent of AT III.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cofrancesco E., Radaelli F., Pogliani E., Amici N., Torri G. G., Casu B. Correlation of sulfate content and degree of carboxylation of heparin and related glycosaminoglycans with anticomplement activity. Relationships to the anticoagulant and platelet-aggregating activities. Thromb Res. 1979 Jan;14(1):179–187. doi: 10.1016/0049-3848(79)90036-7. [DOI] [PubMed] [Google Scholar]
  2. Crawford G. P., Ogston D. The action of antithrombin III on plasmin and activators of plasminogen. Biochim Biophys Acta. 1975 May 23;391(1):189–192. doi: 10.1016/0005-2744(75)90165-5. [DOI] [PubMed] [Google Scholar]
  3. Edward M., Long W. F., Watson H. H., Williamson F. B. Sulphated glycosaminoglycans in regenerating rat liver. Biochem J. 1980 Jun 15;188(3):769–773. doi: 10.1042/bj1880769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Edward M., Watson H. H., Williamson F. B., Long W. F. Changes in glycosaminoglycans during regeneration of rat liver [proceedings]. Biochem Soc Trans. 1979 Aug;7(4):643–645. doi: 10.1042/bst0070643. [DOI] [PubMed] [Google Scholar]
  5. Hatton M. W., Berry L. R., Regoeczi E. Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta. Thromb Res. 1978 Oct;13(4):655–670. doi: 10.1016/0049-3848(78)90155-x. [DOI] [PubMed] [Google Scholar]
  6. Highsmith R. F., Rosenberg R. D. The inhibition of human plasmin by human antithrombin-heparin cofactor. J Biol Chem. 1974 Jul 25;249(14):4335–4338. [PubMed] [Google Scholar]
  7. Kindness G., Long W. F., Williamson F. B., Edward M., Winter J. H., Bennett N. B. Effect of glycosaminoglycans on thrombin-induced clotting of normal and antithrombin III-deficient plasmas. Thromb Res. 1980 Feb 1;17(3-4):539–544. doi: 10.1016/0049-3848(80)90090-0. [DOI] [PubMed] [Google Scholar]
  8. Kindness G., Long W. F., Williamson F. B. Enhancement of antithrombin III activity by carrageenans. Thromb Res. 1979;15(1-2):49–60. doi: 10.1016/0049-3848(79)90051-3. [DOI] [PubMed] [Google Scholar]
  9. Kindness G., Williamson F. B., Long W. F. Involvement of antithrombin III in anticoagulant effects of sulphated polysaccharides [proceedings]. Biochem Soc Trans. 1980 Feb;8(1):82–83. doi: 10.1042/bst0080082. [DOI] [PubMed] [Google Scholar]
  10. LAGUNOFF D., WARREN G. Determination of 2-deoxy-2-sulfoaminohexose content of mucopolysaccharides. Arch Biochem Biophys. 1962 Dec;99:396–400. doi: 10.1016/0003-9861(62)90285-0. [DOI] [PubMed] [Google Scholar]
  11. Lindahl U., Hök M. Glycosaminoglycans and their binding to biological macromolecules. Annu Rev Biochem. 1978;47:385–417. doi: 10.1146/annurev.bi.47.070178.002125. [DOI] [PubMed] [Google Scholar]
  12. Long W. F., Williamson F. B., Kindness G., Edward M., Winter J. H. Effect of sulphated polysaccharides on clotting of plasma deficient in antithrombin III [proceedings]. Biochem Soc Trans. 1980 Apr;8(2):188–189. doi: 10.1042/bst0080188a. [DOI] [PubMed] [Google Scholar]
  13. Malström A., Carlstedt I., Aberg L., Fransson L. A. The copolymeric structure of dermatan sulphate produced by cultured human fibroblasts. Different distribution of iduronic acid and glucuronic acid-containing units in soluble and cell-associated glycans. Biochem J. 1975 Dec;151(3):477–489. doi: 10.1042/bj1510477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Murata K., Nakazawa K., Hamai A. Distribution of acidic glycosaminoglycans in the intima, media and adventitia of bovine aorta and their anticoagulant properties. Atherosclerosis. 1975 Jan-Feb;21(1):93–103. doi: 10.1016/0021-9150(75)90096-9. [DOI] [PubMed] [Google Scholar]
  15. Nader H. B., Takahashi H. K., Straus A. H., Dietrich C. P. Selective distribution of the heparin in mammals: conspicuous presence of heparin in lymphoid tissues. Biochim Biophys Acta. 1980 Jan 3;627(1):40–48. doi: 10.1016/0304-4165(80)90121-x. [DOI] [PubMed] [Google Scholar]
  16. Suzuki S., Suzuki S., Nakamura N., Koizumi T. The heterogeneity of dermatan sulfate and heparan sulfate in rat liver and a shift in the glycosaminoglycan contents in carbon tetrachloride-damaged liver. Biochim Biophys Acta. 1976 Mar 25;428(1):166–181. doi: 10.1016/0304-4165(76)90118-5. [DOI] [PubMed] [Google Scholar]
  17. Tangen O., Bygdeman S. Study of the clotting, esterase and platelet aggregating activities of thrombin, acetylated thrombin and reptilase. Scand J Haematol. 1972;9(4):333–338. doi: 10.1111/j.1600-0609.1972.tb00949.x. [DOI] [PubMed] [Google Scholar]
  18. Teien A. N., Abildgaard U., Hök M. The anticoagulant effect of heparan sulfate and dermatan sulfate. Thromb Res. 1976 Jun;8(6):859–867. doi: 10.1016/0049-3848(76)90014-1. [DOI] [PubMed] [Google Scholar]
  19. Thomas D. P., Lane D. A., Michalski R., Johnson E. A., Kakkar V. V. A heparin analogue with specific action on antithrombin III. Lancet. 1977 Jan 15;1(8003):120–122. doi: 10.1016/s0140-6736(77)91708-1. [DOI] [PubMed] [Google Scholar]
  20. Thomas D. P., Merton R. E., Barrowcliffe T. W., Mulloy B., Johnson E. A. Anti-factor Xa activity of heparan sulphate. Thromb Res. 1979 Feb-Mar;14(2-3):501–506. doi: 10.1016/0049-3848(79)90258-5. [DOI] [PubMed] [Google Scholar]
  21. Wagner W. D., Salisbury B. G. Aortic total glycosaminoglycan and dermatan sulfate changes in atherosclerotic rhesus monkeys. Lab Invest. 1978 Oct;39(4):322–328. [PubMed] [Google Scholar]

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