Abstract
1. The effects of three doses of fenfluramine on feeding and drinking in the rat were examined. 2. Feeding and drinking were subdivided into meals and bouts, and the changes in feeding/drinking were expressed in terms of meal/bout frequency, meal/bout size, meal/bout length, and eating/drinking rate. 3. The changes in these parameters were examined over different time periods after the injection. 4. Significant changes in the distribution of inter-response intervals within meals were found in time period 1 with 5 mg/kg and 10 mg/kg doses of fenfluramine. Videotape and computer analysis showed that the changes in inter-response interval histograms differed significantly from those seen in normal animals approaching satiety. Drinking parameters also changed. 5. Compensatory increases in feeding were observed in time period 4 with the 10 mg/kg dose. 6. The difficulties in designing and interpreting experiments in feeding are discussed, and the action of fenfluramine as an anorectic drug is considered.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blundell J. E. Is there a role for serotonin (5-hydroxytryptamine) in feeding? Int J Obes. 1977;1(1):15–42. [PubMed] [Google Scholar]
- Blundell J. E., Latham C. J., Leshem M. B. Biphasic action of a 5-hydroxytryptamine inhibitor on fenfluramine-induced anorexia. J Pharm Pharmacol. 1973 Jun;25(6):492–494. doi: 10.1111/j.2042-7158.1973.tb09141.x. [DOI] [PubMed] [Google Scholar]
- Blundell J. E., Latham C. J., Leshem M. B. Differences between the anorexic actions of amphetamine and fenfluramine--possible effects on hunger and satiety. J Pharm Pharmacol. 1976 Jun;28(6):471–477. doi: 10.1111/j.2042-7158.1976.tb02768.x. [DOI] [PubMed] [Google Scholar]
- Grinker J. A., Drewnowski A., Enns M., Kissileff H. Effects of d-amphetamine and fenfluramine on feeding pattens and activity of obese and lean Zucker rats. Pharmacol Biochem Behav. 1980 Feb;12(2):265–275. doi: 10.1016/0091-3057(80)90367-6. [DOI] [PubMed] [Google Scholar]
- Jacobs B. L. An animal behavior model for studying central serotonergic synapses. Life Sci. 1976 Sep 15;19(6):777–785. doi: 10.1016/0024-3205(76)90303-9. [DOI] [PubMed] [Google Scholar]
- Kissileff H. R. Free feeding in normal and "recovered lateral" rats monitored by a pellet-detecting eatometer. Physiol Behav. 1970 Feb;5(2):163–173. doi: 10.1016/0031-9384(70)90060-0. [DOI] [PubMed] [Google Scholar]
- Levitsky D. A. Feeding patterns of rats in response to fasts and changes in environmental conditions. Physiol Behav. 1970 Mar;5(3):291–300. doi: 10.1016/0031-9384(70)90101-0. [DOI] [PubMed] [Google Scholar]
- Marsden C. A., Curzon G. The role of tryptamine in the behavioural effects of tranylcypromine + L-tryptophan. Neuropharmacology. 1979 Feb;18(2):159–164. doi: 10.1016/0028-3908(79)90056-x. [DOI] [PubMed] [Google Scholar]
- Panksepp J. Reanalysis of feeding patterns in the rat. J Comp Physiol Psychol. 1973 Jan;82(1):78–94. doi: 10.1037/h0033812. [DOI] [PubMed] [Google Scholar]
- Pinder R. M., Brogden R. N., Sawyer P. R., Speight T. M., Avery G. S. Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. Drugs. 1975;10(4):241–323. doi: 10.2165/00003495-197510040-00001. [DOI] [PubMed] [Google Scholar]
- Reuter C. J. A review of the CNS effects of fenfluramine, 780SE and norfenfluramine on animals and man. Postgrad Med J. 1975;51 (Suppl 1):18–27. [PubMed] [Google Scholar]
- Samanin R., Caccia S., Bendotti C., Borsini F., Borroni E., Invernizzi R., Pataccini R., Mennini T. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl) 1980;68(1):99–104. doi: 10.1007/BF00426657. [DOI] [PubMed] [Google Scholar]