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. 1981 Jun;73(2):385–391. doi: 10.1111/j.1476-5381.1981.tb10433.x

Further studies on 5-hydroxytryptamine transport in pancreatic islets and isolated β-cells

Per Lindström
PMCID: PMC2071649  PMID: 7016232

Abstract

1 The transport mechanism for 3H-labelled 5-hydroxytryptamine (5-HT) in isolated pancreatic islets of non-inbred ob/ob mice was further characterized.

2 Isolated β-cells accumulated 5-HT to the same degree and with the same Na+-dependence as whole islets.

3 Imipramine inhibited the uptake in a concentration-dependent way.

4 Reserpine did not affect the uptake or efflux rates.

5 Glucose stimulation of insulin secretion did not affect the uptake rate.

6 It is concluded that the observed islet uptake of [3H]-5-HT represents an intracellular accumulation by the β-cells. Mechanisms at the level of the plasma membrane may be rate-limiting for this process.

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Selected References

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