Abstract
Nifedipine preferentially blocks contractions of the prostatic end of the rat vas deferens to single pulse field stimulation, leaving the epididymal end largely unaffected. This action is not due entirely to antagonism of calcium influx. Verapamil unexpectedly potentiated the responses of the prostatic portion, and antagonized those of the epididymal end. The use of nifedipine may, therefore, allow investigations of adrenergic mechanisms on this tissue to be studied without the complications of non-adrenergic transmission.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anton P. G., Duncan M. E., McGrath J. C. An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens. J Physiol. 1977 Dec;273(1):23–43. doi: 10.1113/jphysiol.1977.sp012079. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fleckenstein A. Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Annu Rev Pharmacol Toxicol. 1977;17:149–166. doi: 10.1146/annurev.pa.17.040177.001053. [DOI] [PubMed] [Google Scholar]
- McGrath J. C. Adrenergic and 'non-adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus. J Physiol. 1978 Oct;283:23–39. doi: 10.1113/jphysiol.1978.sp012486. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shigenobu K., Schneider J. A., Sperelakis N. Verapamil blockade of slow Na+ and Ca++ responses in myocardial cells. J Pharmacol Exp Ther. 1974 Aug;190(2):280–288. [PubMed] [Google Scholar]