Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1981 Jun;73(2):431–434. doi: 10.1111/j.1476-5381.1981.tb10439.x

Inhibitory effects of propranolol on the calcium current of Helix neurones.

N Akaike, K Nishi, Y Oyama
PMCID: PMC2071676  PMID: 6263388

Abstract

1 Calcium current (ICa) and potassium current (IK) in isolated nerve cell bodies of Helix aspersa were independently separated after suppression of Na+ and K+ currents, and Na+ and Ca2+ currents, respectively. The suction pipette method was used. Under voltage clamp conditions, the effects of propranolol on both the ICa and IK were examined. 2 Propranolol inhibits the ICa at relatively low concentrations (10(-6)-10(-5) M). The inhibitory action was dose-dependent. 3 The IK was moderately suppressed by the drug at high concentrations (10(-5)-5 X 10(-1) M). 4 Results provide evidence for a new aspect of the pharmacological action of propranolol on the excitable cell membrane.

Full text

PDF
431

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akaike N., Lee K. S., Brown A. M. The calcium current of Helix neuron. J Gen Physiol. 1978 May;71(5):509–531. doi: 10.1085/jgp.71.5.509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blaustein M. P., Goldman D. E. Competitive action of calcium and procaine on lobster axon. A study of the mechanism of action of certain local anesthetics. J Gen Physiol. 1966 May;49(5):1043–1063. doi: 10.1085/jgp.49.5.1043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FLECKENSTEIN A. DIE BEDEUTUNG DER ENERGIEREICHEN PHOSPHOSPHATE FUER KONTRAKTILITAET UND TONUS DES MYOKARDS. Verh Dtsch Ges Inn Med. 1964;70:81–99. [PubMed] [Google Scholar]
  4. GILL E. W., WILLIAMS E. M. LOCAL ANAESTHETIC ACTIVITY OF THE BETA-RECEPTOR ANTAGONIST, PRONETHALOL. Nature. 1964 Jan 11;201:199–199. doi: 10.1038/201199a0. [DOI] [PubMed] [Google Scholar]
  5. Hashimoto K., Satoh H., Imai S. Effects of etafenone and antiarrhythmic drugs on Na and Ca channels of guinea pig atrial muscle. J Cardiovasc Pharmacol. 1979 Sep-Oct;1(5):561–570. doi: 10.1097/00005344-197909000-00008. [DOI] [PubMed] [Google Scholar]
  6. Ishida H., Sasa M., Takaori S. Local anesthetic activity of beta-adrenergic blocking drugs in the Crayfish giant axon, with reference to calcium ion. Jpn J Pharmacol. 1980 Oct;30(5):607–619. doi: 10.1254/jjp.30.607. [DOI] [PubMed] [Google Scholar]
  7. Lee K. S., Akaike N., Brown A. M. Properties of internally perfused, voltage-clamped, isolated nerve cell bodies. J Gen Physiol. 1978 May;71(5):489–507. doi: 10.1085/jgp.71.5.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lee K. S., Akaike N., Brown A. M. The suction pipette method for internal perfusion and voltage clamp of small excitable cells. J Neurosci Methods. 1980 Feb;2(1):51–78. doi: 10.1016/0165-0270(80)90045-x. [DOI] [PubMed] [Google Scholar]
  9. MORALES AGUILERA A., VAUGHANWILLIAMS E. M. THE EFFECTS ON CARDIAC MUSCLE OF BETA-RECEPTOR ANTAGONISTS IN RELATION TO THEIR ACTIVITY AS LOCAL ANAESTHETICS. Br J Pharmacol Chemother. 1965 Apr;24:332–338. doi: 10.1111/j.1476-5381.1965.tb01719.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Narahashi T., Moore J. W., Poston R. N. Anesthetic blocking of nerve membrane conductances by internal and external applications. J Neurobiol. 1969;1(1):3–22. doi: 10.1002/neu.480010103. [DOI] [PubMed] [Google Scholar]
  11. Parmley W. W., Braunwald E. Comparative myocardial depressant and anti-arrhythmic properties of d-propranolol, dl-propranolol and quinidine. J Pharmacol Exp Ther. 1967 Oct;158(1):11–21. [PubMed] [Google Scholar]
  12. SHANES A. M., FREYGANG W. H., GRUNDFEST H., AMATNIEK E. Anesthetic and calcium action in the voltage-clamped squid giant axon. J Gen Physiol. 1959 Mar 20;42(4):793–802. doi: 10.1085/jgp.42.4.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sasa M., Avner B. P., Albuquerque E. X. Actions of beta-blocking agents on membrane excitability of the lobster giant axon. Eur J Pharmacol. 1973 Jul;23(1):97–103. doi: 10.1016/0014-2999(73)90249-5. [DOI] [PubMed] [Google Scholar]
  14. TAYLOR R. E. Effect of procaine on electrical properties of squid axon membrane. Am J Physiol. 1959 May;196(5):1071–1078. doi: 10.1152/ajplegacy.1959.196.5.1071. [DOI] [PubMed] [Google Scholar]
  15. Thompson S. H. Three pharmacologically distinct potassium channels in molluscan neurones. J Physiol. 1977 Feb;265(2):465–488. doi: 10.1113/jphysiol.1977.sp011725. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES