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. 1981 Jun;73(2):405–408. doi: 10.1111/j.1476-5381.1981.tb10436.x

Partial agonist behaviour of adenosine 5'-O-(2-thiodiphosphate) on human platelets.

N J Cusack, S M Hourani
PMCID: PMC2071680  PMID: 7236992

Abstract

1 The effects of an adenosine diphosphate (ADP) analogue, adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S), in which a terminal phosphate oxygen has been replaced by sulphur, were studied on human platelets. 2 ADP-beta-S induced platelet aggregation and inhibited prostaglandin E1 (PGE1)-stimulated adenylate cyclase but in both cases was less potent than ADP and did not achieve the same maximal effects. 3 Both actions of ADP could be inhibited by the simultaneous addition of ADP-beta-S (50 microM). 4 Aggregation induced by 11 alpha, 9 alpha-epoxymethano prostaglandin H2 (a stable endoperoxide analogue) was not inhibited by simultaneous addition of ADP-beta-S (50 microM). 5 The behaviour of ADP-beta-S towards human platelets was consistent with it being a partial agonist.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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