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. 1981 Jul;73(3):586–588. doi: 10.1111/j.1476-5381.1981.tb16791.x

alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.

N A Flavahan, J C McGrath
PMCID: PMC2071683  PMID: 6265015

Abstract

In the pithed rat, amidephrine a "selective" alpha 1-adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to cardioaccelerator nerve stimulation is resistant to blockade by propranolol but is sensitive to prazosin or WB4101. We conclude that alpha 1-adrenoceptors can mediate a chronotropic response in the rat heart either to exogenous agonists or to the endogenous neurotransmitter noradrenaline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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