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. 1981 Jul;73(3):691–694. doi: 10.1111/j.1476-5381.1981.tb16804.x

Divalent cations increase [3H]-prostacyclin binding to membranes of neuronal somatic hybrid cells.

I A Blair, T M Cresp, J MacDermot
PMCID: PMC2071688  PMID: 7018637

Abstract

1 [3H]-prostacyclin binding to membranes of a highly differentiated neuronal somatic hybrid is increased equally in the presence of Ca2+, Ba2+, Mg2+ or Sr2+ ions. 2 Analysis of the binding of [3H]-prostacyclin in the presence of low (1 mM) or high (50 mM) Mg2+ ion concentrations has revealed a cation-dependent increase in ligand receptor affinity (Kd values = 57.4 nM and 21.9 nM). 3 The increase in [3H]-prostacyclin binding due to divalent cations is not accompanied by an alteration in the maximum binding capacity of the membranes.

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Selected References

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