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. 1982 Aug;76(4):523–526. doi: 10.1111/j.1476-5381.1982.tb09249.x

A comparative study of beta-adrenoceptors in human and porcine lung parenchyma strip.

R G Goldie, J W Paterson, J L Wale
PMCID: PMC2071830  PMID: 6286028

Abstract

1. Responses to (+/-)-isoprenaline (Iso), (-)-adrenaline (Adr) and (-)-noradrenaline (NA) were compared in isolated preparations of human and porcine lung parenchyma strip. 2. The order of relaxant potencies of these catecholamines in both human and porcine lung parenchyma was Iso greater than Adr greater than NA (1:0.24:0.01, human; 1:0.21:0.01.pig). These results suggest that beta 2-adrenoceptors predominate in both types of lung parenchyma strip. 3. pA2 values for the beta-adrenoceptor antagonist, propranolol (non-selective), with Iso as the agonist, in human and porcine lung strips were 7.84 and 7.83 respectively and for atenolol were 6.50 and 5.35 respectively. Taken as a whole results indicate the existence of an apparently homogeneous population of beta 2-adrenoceptors in porcine parenchyma strip, while both beta 1 and beta 2-adrenoceptors were revealed in human lung parenchyma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARUNLAKSHANA O., SCHILD H. O. Some quantitative uses of drug antagonists. Br J Pharmacol Chemother. 1959 Mar;14(1):48–58. doi: 10.1111/j.1476-5381.1959.tb00928.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barrett A. M. The pharmacology of atenolol. Postgrad Med J. 1977;53 (Suppl 3):58–64. [PubMed] [Google Scholar]
  3. Black J., Turner A., Shaw J. alpha-adrenoceptors in human peripheral lung. Eur J Pharmacol. 1981 Jun 10;72(1):83–86. doi: 10.1016/0014-2999(81)90300-9. [DOI] [PubMed] [Google Scholar]
  4. Bristow M., Sherrod T. R., Green R. D. Analysis of beta receptor drug interactions in isolated rabbit atrium, aorta, stomach and trachea. J Pharmacol Exp Ther. 1970 Jan;171(1):52–61. [PubMed] [Google Scholar]
  5. Carlsson E., Dahlöf C. G., Hedberg A., Persson H., Tångstrand B. Differentiation of cardiac chronotropic and inotropic effects of beta-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol. 1977 Nov;300(2):101–105. doi: 10.1007/BF00505039. [DOI] [PubMed] [Google Scholar]
  6. Chan-Yeung M., Abboud R., Tsao M. S., Maclean L. Effect of helium on maximal expiratory flow in patients with asthma before and during induced bronchoconstriction. Am Rev Respir Dis. 1976 Apr;113(4):433–443. doi: 10.1164/arrd.1976.113.4.433. [DOI] [PubMed] [Google Scholar]
  7. Despas P. J., Leroux M., Macklem P. T. Site of airway obstruction in asthma as determined by measuring maximal expiratory flow breathing air and a helium-oxygen mixture. J Clin Invest. 1972 Dec;51(12):3235–3243. doi: 10.1172/JCI107150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Foster R. W. A correlation between inhibition of the uptake of 3H from (+)-3H-noradrenaline and potentiation of the responses to (-)-noradrenaline in the guinea-pig isolated trachea. Br J Pharmacol Chemother. 1968 Jun;33(2):357–367. doi: 10.1111/j.1476-5381.1968.tb00996.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Foster R. W. An uptake of radioactivity from (plus or minus)-3H-isoprenaline and its inhibition by drugs which potentiate the responses to (minus)-isoprenaline in the guinea-pig isolated trachea. Br J Pharmacol. 1969 Mar;35(3):418–427. doi: 10.1111/j.1476-5381.1969.tb08283.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Goldie R. G., Paterson J. W. Catecholamine transport in isolated lung parenchyma of pig. Br J Pharmacol. 1982 Aug;76(4):507–513. doi: 10.1111/j.1476-5381.1982.tb09247.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harms H. H. Isoproterenol antagonism of cardioselective beta adrenergic receptor blocking agents: a comparative study of human and guinea-pig cardiac and bronchial beta adrenergic receptors. J Pharmacol Exp Ther. 1976 Nov;199(2):329–335. [PubMed] [Google Scholar]
  12. Lands A. M., Arnold A., McAuliff J. P., Luduena F. P., Brown T. G., Jr Differentiation of receptor systems activated by sympathomimetic amines. Nature. 1967 May 6;214(5088):597–598. doi: 10.1038/214597a0. [DOI] [PubMed] [Google Scholar]
  13. Lulich K. M., Mitchell H. W., Sparrow M. P. The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. Br J Pharmacol. 1976 Sep;58(1):71–79. doi: 10.1111/j.1476-5381.1976.tb07694.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mirbahar K. B., Eyre P. Bovine lung parenchyma strip has both airway and vascular characteristics. (Pharmacological comparisons with bronchus, pulmonary artery and vein). Res Commun Chem Pathol Pharmacol. 1980 Jul;29(1):15–25. [PubMed] [Google Scholar]
  15. O'Donnell S. R. An examination of some -adrenoreceptor stimulants for selectivity using the isolated trachea and atria of the guinea pig. Eur J Pharmacol. 1972 Sep;19(3):371–379. doi: 10.1016/0014-2999(72)90104-5. [DOI] [PubMed] [Google Scholar]
  16. O'Donnell S. R., Wanstall J. C. The importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria. Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):183–190. doi: 10.1007/BF00501381. [DOI] [PubMed] [Google Scholar]
  17. Paterson J. W., Woolcock A. J., Shenfield G. M. Bronchodilator drugs. Am Rev Respir Dis. 1979 Nov;120(5):1149–1188. doi: 10.1164/arrd.1979.120.5.1149. [DOI] [PubMed] [Google Scholar]
  18. Siegl P. K., Rossi G. V., Orzechowski R. F. Isolated lung strips of guinea pigs: responses to beta-adrenergic agonists and antagonists. Eur J Pharmacol. 1979 Feb 15;54(1-2):1–7. doi: 10.1016/0014-2999(79)90400-x. [DOI] [PubMed] [Google Scholar]
  19. Toda N., Hayashi S., Hatano Y., Okunishi H., Miyazaki M. Selectivity and steric effects of metoprolol isomers on isolated rabbit atria, arteries and tracheal muscles. J Pharmacol Exp Ther. 1978 Nov;207(2):311–319. [PubMed] [Google Scholar]
  20. van der Heijden P. J., Zaagsma J. Characterization of the beta-adrenoceptors in guinea-pig lung mast cells [proceedings]. Br J Pharmacol. 1980 Jan;68(1):152P–152P. [PMC free article] [PubMed] [Google Scholar]

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