Abstract
1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was not affected by the presence of verapamil. 3 The pulmonary pressor effect of PGF2 alpha and U-46619 is dependent, at least in part, on Ca2+ influx into vascular smooth muscle cells. 4 The pulmonary pressor response to AA cannot be attributed to PGF2 alpha or to endoperoxide intermediates but to some other product dependent on intracellular calcium stores.
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Selected References
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- Deth R., van Breemen C. Relative contributions of Ca2+ influx and cellular Ca2+ release during drug induced activation of the rabbit aorta. Pflugers Arch. 1974 Apr 4;348(1):13–22. doi: 10.1007/BF00587735. [DOI] [PubMed] [Google Scholar]
- Devine C. E., Somlyo A. V., Somlyo A. P. Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscles. J Cell Biol. 1972 Mar;52(3):690–718. doi: 10.1083/jcb.52.3.690. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fitzpatrick T. M., Alter I., Corey E. J., Ramwell P. W., Rose J. C., Kot P. A. Antagonism of the pulmonary vasoconstrictor response to prostaglandin F2alpha by N-dimethylamino substitution of prostaglandin F2alpha. J Pharmacol Exp Ther. 1978 Jul;206(1):139–142. [PubMed] [Google Scholar]
- Hurwitz L., Joiner P. D., Von Hagen S. Calcium pools utilized for contraction in smooth muscle. Am J Physiol. 1967 Nov;213(5):1299–1304. doi: 10.1152/ajplegacy.1967.213.5.1299. [DOI] [PubMed] [Google Scholar]
- Rose J. C., Kot A., Ramwell W., Doykos M., O'Neill W. P. Cardiovascular responses to three prostaglandin endoperoxide analogs in the dog. Proc Soc Exp Biol Med. 1976 Nov;153(2):209–212. doi: 10.3181/00379727-153-39512. [DOI] [PubMed] [Google Scholar]
- Wicks T. C., Rose J. C., Johnson M., Ramwell P. W., Kot P. A. Vascular responses to arachidonic acid in the perfused canine lung. Circ Res. 1976 Mar;38(3):167–171. doi: 10.1161/01.res.38.3.167. [DOI] [PubMed] [Google Scholar]