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. 1981 Sep;74(1):105–109. doi: 10.1111/j.1476-5381.1981.tb09960.x

Potentiation by naloxone of pressor reflexes.

J L Montastruc, P Montastruc, F Morales-Olivas
PMCID: PMC2071865  PMID: 7272594

Abstract

1 The effect of intravenous naloxone, and opiate antagonist, was studied on the pressor responses elicited by stimulation of afferent nerves (vagus and laryngeal superior nerves) in anaesthetized dogs. 2 Although naloxone (0.1 mg/kg i.v.) alone failed to modify basic blood pressure, the pressor responses induced by stimulation of either the vagus or laryngeal nerve were potentiated by naloxone. 3 Morphine (0.2 mg/kg i.v.) suppressed these two cardiovascular responses. These depressor effects of morphine were reversed by subsequent injection of naloxone (0.1 mg/kg i.v.). 4 The results suggest the involvement of endogenous opiate peptides in pressor reflexes elicited by stimulation of the afferent nerves.

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Selected References

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