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. 1981 Sep;74(1):155–159. doi: 10.1111/j.1476-5381.1981.tb09968.x

The effects of prostaglandins E2, F2 alpha, prostacyclin, flurbiprofen and aspirin on arrhythmias resulting from coronary artery ligation in anaesthetized rats.

S J Coker, J R Parratt
PMCID: PMC2071878  PMID: 7023587

Abstract

1 Various prostaglandins and inhibitors of prostaglandin synthesis were administered prior to acute coronary artery ligation in anaesthetized rats and their effects were assessed on the number and severity of the resulting early arrhythmias (ventricular ectopic activity; incidence and duration of ventricular tachycardia and of ventricular fibrillation). 2 Prostaglandin E2 (PGE2), PGF2 alpha and prostacyclin all showed antiarrhythmic activity; in contrast flurbiprofen increased the incidence of ventricular fibrillation and mortality. 3 Both the number of ventricular ectopic beats and the incidence of ventricular fibrillation were reduced by aspirin. 4 The results suggest that the release of endogenous PGE2, PGF2 alpha and prostacyclin could reduce early post-infarction ventricular arrhythmias whilst the protective effect of aspirin in this model adds further support for the hypothesis that thromboxane release is involved in the genesis of these arrhythmias.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Au T. L., Collins G. A., Harvie C. J., Walker M. J. The actions of prostaglandins I2 and E2 on arrhythmias produced by coronary occlusion in the rat and dog. Prostaglandins. 1979 Nov;18(5):707–720. doi: 10.1016/0090-6980(79)90091-1. [DOI] [PubMed] [Google Scholar]
  2. Clark C., Foreman M. I., Kane K. A., McDonald F. M., Parratt J. R. Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size. J Pharmacol Methods. 1980 Jun;3(4):357–368. doi: 10.1016/0160-5402(80)90077-7. [DOI] [PubMed] [Google Scholar]
  3. Coker S. J., Ledingham I. M., Parratt J. R., Zeitlin I. J. Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. Br J Pharmacol. 1981 Apr;72(4):593–595. doi: 10.1111/j.1476-5381.1981.tb09138.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coker S. J., Parratt J. R., Ledingham I. M., Zeitlin I. J. Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias. Nature. 1981 May 28;291(5813):323–324. doi: 10.1038/291323a0. [DOI] [PubMed] [Google Scholar]
  5. Dix R. K., Kelliher G. J., Jurkiewicz N., Lawrence T. The influence of prostacyclin on coronary occlusion induced arrhythmia in cats. Prostaglandins Med. 1979 Sep;3(3):173–184. doi: 10.1016/0161-4630(79)90101-0. [DOI] [PubMed] [Google Scholar]
  6. Fitzpatrick F. A., Wynalda M. A. In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents. Prostaglandins. 1976 Dec;12(6):1037–1051. doi: 10.1016/0090-6980(76)90137-4. [DOI] [PubMed] [Google Scholar]
  7. Förster W., Mest H. J., Mentz P. The influence of PGF2 alpha on experimental arrhythmias. Prostaglandins. 1973 Jun;3(6):895–904. doi: 10.1016/0090-6980(73)90013-0. [DOI] [PubMed] [Google Scholar]
  8. Förster W. Prostaglandins and prostaglandin precursors as endogenous antiarrhythmic principles of the heart. Acta Biol Med Ger. 1976;35(8-9):1101–1112. [PubMed] [Google Scholar]
  9. Harvie C. J., Collins G. A., Miyagishima R. T., Walker M. J. The action of prostaglandin E2 and F1alpha on myocardial ischaemia-infarction arrhythmias in the dog. Prostaglandins. 1978 Dec;16(6):885–899. doi: 10.1016/0090-6980(78)90104-1. [DOI] [PubMed] [Google Scholar]
  10. Korbut R., Moncada S. Prostacyclin (PGI2) and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy. Thromb Res. 1978 Sep;13(3):489–500. doi: 10.1016/0049-3848(78)90134-2. [DOI] [PubMed] [Google Scholar]
  11. Moschos C. B., Haider B., De La Cruz C., Jr, Lyons M. M., Regan T. J. Antiarrhythmic effects of aspirin during nonthrombotic coronary occlusion. Circulation. 1978 Apr;57(4):681–684. doi: 10.1161/01.cir.57.4.681. [DOI] [PubMed] [Google Scholar]
  12. Moschos C. B., Haider B., Escobinas A. J., Gandhi A., Regan T. J. Chronic use of aspirin versus indomethacin during non-thrombotic myocardial ischemia: effects on survival. Am Heart J. 1980 Nov;100(5):647–652. doi: 10.1016/0002-8703(80)90229-x. [DOI] [PubMed] [Google Scholar]
  13. Smith J. B., Willis A. L. Aspirin selectively inhibits prostaglandin production in human platelets. Nat New Biol. 1971 Jun 23;231(25):235–237. doi: 10.1038/newbio231235a0. [DOI] [PubMed] [Google Scholar]
  14. Somberg J. C., Bounous H., Cagin N., Anagnostopoulos C., Levitt B. The influence of prostaglandins E1 and E2 on ouabain cardiotoxicity in the cat. J Pharmacol Exp Ther. 1977 Nov;203(2):480–484. [PubMed] [Google Scholar]
  15. Zijlstra W. G., Brunsting J. R., ten Hoor F., Vergroesen A. J. Prostaglandin E 1 and cardiac arrhythmia. Eur J Pharmacol. 1972 May;18(3):392–395. doi: 10.1016/0014-2999(72)90041-6. [DOI] [PubMed] [Google Scholar]
  16. de Deckere E. A., Nugteren D. H., Ten Hoor F. Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart. Nature. 1977 Jul 14;268(5616):160–163. doi: 10.1038/268160a0. [DOI] [PubMed] [Google Scholar]

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