Skip to main content
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1969 Feb;50(1):22–25.

Effects of Diet and Microsomal Enzyme Induction on the Toxicity of Dimethyl Nitrosamine

A E M McLean, H G Verschuuren
PMCID: PMC2072096  PMID: 5773143

Abstract

Feeding a protein free diet protects rats against the lethal and hepatotoxic effects of dimethyl nitrosamine. The protection cannot be reversed by starvation or by treatments which restore microsomal enzyme activity (phenobarbital or DDT). The cause of the protective effect is unknown.

Full text

PDF
22

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Lijinsky W., Loo J., Ross A. E. Mechanism of alkylation of nucleic acids by nitrosodimethylamine. Nature. 1968 Jun 22;218(5147):1174–1175. doi: 10.1038/2181174b0. [DOI] [PubMed] [Google Scholar]
  2. McLean A. E., McLean E. K. The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning. Biochem J. 1966 Aug;100(2):564–571. doi: 10.1042/bj1000564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Orrenius S., Ericsson J. L., Ernster L. Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J Cell Biol. 1965 Jun;25(3):627–639. doi: 10.1083/jcb.25.3.627. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Experimental Pathology are provided here courtesy of Wiley

RESOURCES