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. 1969 Feb;50(1):84–96.

Effect of Endotoxin from Serratia marcescens on the Permeability of Vessels in Hepatomas and Carrageenin Granulomas of Rats

N T A Oswald, D B Cater
PMCID: PMC2072097  PMID: 4304259

Abstract

Serratia marcescens polysaccharide (endotoxin) was injected i.v. into rats bearing carrageenin-induced granulomas and transplanted hepatomas, and the vascular-permeability changes were studied by injecting Pelikan ink i.v. at various times after the endotoxin (or saline in the controls).

When the ink was given at 0 or 1 hr. there was little difference between the treated rats and the controls. But when the ink was given 2 or more hr. after the endotoxin there was a marked increase of the carbon-lined capillaries and venules, compared with controls, in tumour, granuloma, glomeruli, adrenal cortex, lung, lymph-nodes and sometimes heart. The significance of these changes is discussed in relation to the Shwartzman phenomenon, Arthus reaction, and adrenaline-induced vascular spasm producing anoxia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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