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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1969 Apr;50(2):165–171.

Progesterone Metabolism by Adrenal Homogenates of Rats Treated with 7,12-dimethylbenz(a)anthracene*

E Dale, F D Scutchfield
PMCID: PMC2072152  PMID: 5772070

Abstract

[4-14C]-progesterone has been incubated with adrenal homogenates prepared from rats which had been administered the carcinogen, 7,12-dimethylbenz[a]-anthracene. The production of corticosterone was reduced markedly in preparations from treated animals when compared to untreated control animals. During the second week following treatment, an increased synthesis of corticosterone and other adrenal cortical steroids becomes evident. The relationship between adrenal cortical pathology, circulating plasma corticosterone levels and impairment of biosynthetic hydroxylating enzyme systems following administration of the carcinogen is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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