Abstract
The vascular exudative response to cutaneous crush injury was studied in the rat by estimating the leakage of circulating Evans' blue as well as by labelling abnormally permeable vessels with circulating colloidal carbon.
The time-course of increased vascular permeability evoked by moderate crush injury is characterized by a monophasic response which has a rapid onset and lasts no more than 4 hr. Increments in the intensity and/or duration of the stimulus are matched by increased intensity and duration of the monophasic response, but with strong crushing the initial phase is followed by a second or delayed response occurring 3-6 hr after injury. Labelling with circulating colloidal carbon indicates that in both phases of the permeability response, the effects are confined to venules.
Antagonists of histamine and serotonin partially suppress exudation in the initial ½ hr after injury, whereas antagonists of kinins and serotonin partially suppress the delayed phase of exudation.
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