Skip to main content
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1970 Jun;51(3):322–327.

Plasma Kinins in Synovial Exudates

V Eisen
PMCID: PMC2072272  PMID: 5429076

Abstract

Kinin levels equivalent to 1-30 × 10-9 m bradykinin were found in 33 out of 82 exudates from rheumatoid joints. Only 2 of 27 fluids from joint effusions caused by osteoarthrosis or trauma, contained detectable levels of kinin (1-5 × 10-9 m bradykinin). The kinin concentrations showed little or no correlation with the white blood cell counts, protein concentrations and lactate dehydrogenase and acid phosphatase activities, in synovial fluids. Data on the pain felt in joints suggested that in higher concentrations kinins contribute to arthritic pain, but that other pain-producing factors are undoubtedly involved.

Full text

PDF
322

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMSTRONG D., JEPSON J. B., KEELE C. A., STEWART J. W. Pain-producing substance in human inflammatory exudates and plasma. J Physiol. 1957 Feb 15;135(2):350–370. doi: 10.1113/jphysiol.1957.sp005715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eisen V. Urates and kinin formation in synovial fluid. Proc R Soc Med. 1966 Apr;59(4):302–307. [PMC free article] [PubMed] [Google Scholar]
  3. Greenbaum L. M., Yamafuji K. The in vitro inactivation and formation of plasma kinins by spleen cathepsins. Br J Pharmacol Chemother. 1966 May;27(1):230–238. doi: 10.1111/j.1476-5381.1966.tb01658.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jasani M. K., Katori M., Lewis G. P. Intracellular enzymes and kinin enzymes in synovial fluid in joint diseases. Origin and relation to disease category. Ann Rheum Dis. 1969 Sep;28(5):497–512. doi: 10.1136/ard.28.5.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  6. MILES A. A. LARGE MOLECULAR SUBSTANCES AS MEDIATORS OF THE INFLAMMATORY REACTION. Ann N Y Acad Sci. 1964 Aug 27;116:855–865. doi: 10.1111/j.1749-6632.1964.tb52551.x. [DOI] [PubMed] [Google Scholar]
  7. SAAMELI K., ESKES T. K. Bradykinin and cardiovascular system: estimation of half-life. Am J Physiol. 1962 Aug;203:261–265. doi: 10.1152/ajplegacy.1962.203.2.261. [DOI] [PubMed] [Google Scholar]
  8. SCHACHTER M. A delayed slow contracting effect of serum and plasma due to the release of a substance resembling kallidin and bradykinin. Br J Pharmacol Chemother. 1956 Jun;11(2):111–118. doi: 10.1111/j.1476-5381.1956.tb01038.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Talamo R. C., Haber E., Austen K. F. A radioimmunoassay for bradykinin in plasma and synovial fluid. J Lab Clin Med. 1969 Nov;74(5):816–827. [PubMed] [Google Scholar]
  10. Vane J. R. The release and fate of vaso-active hormones in the circulation. Br J Pharmacol. 1969 Feb;35(2):209–242. doi: 10.1111/j.1476-5381.1969.tb07982.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. WROBLEWSKI F., LADUE J. S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med. 1955 Oct;90(1):210–213. doi: 10.3181/00379727-90-21985. [DOI] [PubMed] [Google Scholar]
  12. Zachariae H., Malmquist J., Oates J. A. Kininase in human polymorphonuclear leukocytes. Life Sci. 1966 Dec;5(24):2347–2355. doi: 10.1016/0024-3205(66)90072-5. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Experimental Pathology are provided here courtesy of Wiley

RESOURCES