Abstract
Groups of mice, inoculated once a week for 3 weeks with vaccines from culture filtrates of Pseudomonas aeruginosa and Proteus mirabilis and slime from Klebsiella aerogenes, were protected against lethal infections with the homologous strains injected intraperitoneally after burning.
A single injection of pseudomonas and proteus vaccines also protected burned and unburned mice against lethal, homologous, i.p. infections as early as 24-48 hr after vaccination. The klebsiella vaccine did not induce early protection. A single injection of a trivalent vaccine, made by combining pseudomonas, proteus and klebsiella vaccines in equal proportions, protected burned mice against lethal K. aerogenes, Ps. aeruginosa and Pr. mirabilis infections.
Mice which were protected against homologous infections had no detectable agglutinins in their sera until three days after the protective response had been demonstrated.
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Selected References
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