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. 1971 Feb;52(1):14–22.

Plasminogen Activator of the Blood Vessels in Tumours and in Carrageenin-induced Granulomas

C R Pick, D B Cater
PMCID: PMC2072286  PMID: 5547651

Abstract

Fibrinolytic activity in tumours was studied by the fibrin slide technique. The tumour cells were inactive and fibrinolysis was seen only in areas with young blood vessels. In carrageenin-induced granulomas at 6 days the fibrinolytic activity was small and confined to mature veins, but from 7-14 days activity was high in zones containing young vessels supplying the terminal capillary buds; these latter showed no activity. In old fibrosed granulomas there was no fibrinolytic activity. The vascular permeability changes of inflammation (detected by the colloidal carbon technique) showed no correlation with fibrinolytic activity, and systemic injection of inflammatory agents had no effect on the fibrinolytic activity of the vessels. These findings are discussed in relationship to tumour vascularization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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