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. 1971 Jun;52(3):244–251.

The Effect of Oral Trypsin Inhibitor on Pancreatic Damage in the Rat

R C Pirola, I P Beswick, I A D Bouchier
PMCID: PMC2072321  PMID: 5090685

Abstract

A study has been made of the influence of experimentally-induced pancreatic enlargement on pancreatic damage. Soybean trypsin inhibitor was fed to rats in doses sufficient to produce pancreatic enlargement. This agent was given both before and after the production of pancreatic necrosis by oral d,1-ethionine and before the induction of pancreatitis by ligation of the pancreatico-biliary duct. Generally there was no difference between the severity of pancreatic damage in rats fed trypsin inhibitor and in those on control diets. An exception was in rats given d,1-ethionine after treatment with soybean trypsin inhibitor. In these rats histology showed a less severe form of pancreatic necrosis.

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248-3Figs. 5-6
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248-1Figs. 3-4
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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. GOLDBARG J. A., RUTENBURG A. M. The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases. Cancer. 1958 Mar-Apr;11(2):283–291. doi: 10.1002/1097-0142(195803/04)11:2<283::aid-cncr2820110209>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  2. Khayambashi H., Lyman R. L. Secretion of rat pancreas perfused with plasma from rats fed soybean trypsin inhibitor. Am J Physiol. 1969 Sep;217(3):646–651. doi: 10.1152/ajplegacy.1969.217.3.646. [DOI] [PubMed] [Google Scholar]
  3. Konijn A. M., Birk Y., Guggenheim K. In vitro synthesis of pancreatic enzymes: effect of soybean trypsin inhibitor. Am J Physiol. 1970 Apr;218(4):1113–1117. doi: 10.1152/ajplegacy.1970.218.4.1113. [DOI] [PubMed] [Google Scholar]
  4. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  5. LYMAN R. L., WILCOX S. S., MONSEN E. R. Pancreatic enzyme secretion produced in the rat by trypsin inhibitors. Am J Physiol. 1962 Jun;202:1077–1082. doi: 10.1152/ajplegacy.1962.202.6.1077. [DOI] [PubMed] [Google Scholar]
  6. Lepkovsky S., Koike T., Sugiura M., Dimick M. K., Furuta F. Pancreatic amylase in chickens fed on soya-bean diets. Br J Nutr. 1966;20(3):421–437. doi: 10.1079/bjn19660044. [DOI] [PubMed] [Google Scholar]
  7. Melmed R. N., Bouchier I. A. A further physiological role for naturally occurring trypsin inhibitors: the evidence for a trophic stimulant of the pancreatic acinar cell. Gut. 1969 Dec;10(12):973–979. doi: 10.1136/gut.10.12.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rackis J. J. Physiological properties of soybean trypsin inhibitors and their relationship to pancreatic hypertrophy and growth inhibition of rats. Fed Proc. 1965 Nov-Dec;24(6):1488–1493. [PubMed] [Google Scholar]
  9. Rothman S. S., Wells H. Selective effects of dietary egg white trypsin inhibitor on pancreatic enzyme secretion. Am J Physiol. 1969 Mar;216(3):504–507. doi: 10.1152/ajplegacy.1969.216.3.504. [DOI] [PubMed] [Google Scholar]

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