Abstract
Serum of mice which had been inoculated 3 days previously with a vaccine (P14F1) prepared from a strain of Pseudomonas aeruginosa P14 gave passive protection to unvaccinated mice against a lethal i.p. challenge by Ps. aeruginosa P14. The serum which protected mice against Ps. aeruginosa P14 did not agglutinate suspensions of this organism. Its capacity to protect unvaccinated mice was removed by absorption with Ps. aeruginosa P14, but not by absorption with an unrelated strain of Ps. aeruginosa; passive protective capacity was removed also by absorption with a strain of Klebsiella aerogenes but not by absorption with a strain of Proteus mirabilis. Serum from recently vaccinated mice had no bactericidal activity against the immunizing strain; heparinized blood taken from such mice usually showed no bactericidal action, but there was consistently poorer growth of the pseudomonas in blood from recently vaccinated mice, or from mice passively protected by serum from the recently vaccinated, than in blood from unvaccinated mice.
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Selected References
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- Alexander J. W., Fisher M. W., MacMillan B. G., Altemeier W. A. Prevention of invasive pseudomonas infection in burns with a new vaccine. Arch Surg. 1969 Aug;99(2):249–256. doi: 10.1001/archsurg.1969.01340140121018. [DOI] [PubMed] [Google Scholar]
- Bauer D. C., Stavitsky A. B. ON THE DIFFERENT MOLECULAR FORMS OF ANTIBODY SYNTHESIZED BY RABBITS DURING THE EARLY RESPONSE TO A SINGLE INJECTION OF PROTEIN AND CELLULAR ANTIGENS. Proc Natl Acad Sci U S A. 1961 Oct;47(10):1667–1680. doi: 10.1073/pnas.47.10.1667. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COLEBROOK L., LOWBURY E. J., HURST L. The growth and death of wound bacteria in serum, exudate and slough. J Hyg (Lond) 1960 Dec;58:357–366. doi: 10.1017/s0022172400038493. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carney S. A., Jones R. J. Biological and immunochemical properties of culture filtrates of virulent and avirulent strains of Pseudomonas aeruginosa. Br J Exp Pathol. 1968 Oct;49(5):395–410. [PMC free article] [PubMed] [Google Scholar]
- FOX J. E., LOWBURY E. J. Immunity and antibody to Pseudomonas pyocyanea in rabbits. J Pathol Bacteriol. 1953 Apr;65(2):533–542. doi: 10.1002/path.1700650225. [DOI] [PubMed] [Google Scholar]
- Fisher M. W., Devlin H. B., Gnabasik F. J. New immunotype schema for Pseudomonas aeruginosa based on protective antigens. J Bacteriol. 1969 May;98(2):835–836. doi: 10.1128/jb.98.2.835-836.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROBBINS J. B., KENNY K., SUTER E. THE ISOLATION AND BIOLOGICAL ACTIVITIES OF RABBIT GAMMA M- AND GAMMA G-ANTI-SALMONELLA TYPHIMURIUM ANTIBODIES. J Exp Med. 1965 Aug 1;122:385–402. doi: 10.1084/jem.122.2.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rowley D., Turner K. J. Number of molecules of antibody required to promote phagocytosis of one bacterium. Nature. 1966 Apr 30;210(5035):496–498. doi: 10.1038/210496a0. [DOI] [PubMed] [Google Scholar]
- Sultzer B. M. Endotoxin-induced resistance to a staphylococcal infection: cellular and humoral responses compared in two mouse strains. J Infect Dis. 1968 Jun;118(3):340–348. doi: 10.1093/infdis/118.3.340. [DOI] [PubMed] [Google Scholar]
- UHR J. W., FINKELSTEIN M. S. Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunological memory to bacteriophage phi-X 174. J Exp Med. 1963 Mar 1;117:457–477. doi: 10.1084/jem.117.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]