Abstract
The composition of the lung lipids from animals poisoned with paraquat 2 days and 6 days after treatment has been compared with that from controls. After 6 days, but not after 2 days, there was a large increase in the proportion of arachidonic acid and a small increase in the cholesterol ester fraction. No differences were seen in the phospholipid fractions examined. Analysis of the lipids of peritoneal and alveolar macrophages has shown that the changes in the lungs can be mainly attributed to the increase in numbers of alveolar but not peritoneal macrophages.
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- BROWN E. S. ISOLATION AND ASSAY OF DIPALMITYL LECITHIN IN LUNG EXTRACTS. Am J Physiol. 1964 Aug;207:402–406. doi: 10.1152/ajplegacy.1964.207.2.402. [DOI] [PubMed] [Google Scholar]
- Clark D. G., McElligott T. F., Hurst E. W. The toxicity of paraquat. Br J Ind Med. 1966 Apr;23(2):126–132. doi: 10.1136/oem.23.2.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Conning D. M., Fletcher K., Swan A. A. Paraquat and related bipyridyls. Br Med Bull. 1969 Sep;25(3):245–249. doi: 10.1093/oxfordjournals.bmb.a070712. [DOI] [PubMed] [Google Scholar]
- GOERANSSON G., OLIVECRONA T. THE METABOLISM OF FATTY ACIDS IN THE RAT. I. PALMITIC ACID. Acta Physiol Scand. 1964 Nov;62:224–239. doi: 10.1111/j.1748-1716.1964.tb03970.x. [DOI] [PubMed] [Google Scholar]
- GRAY G. M., MACFARLANE M. G. Composition of phospholipids of rabbit, pigeon and trout muscle and various pig tissues. Biochem J. 1961 Dec;81:480–488. doi: 10.1042/bj0810480. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gage J. C. The action of paraquat and diquat on the respiration of liver cell fractions. Biochem J. 1968 Oct;109(5):757–761. doi: 10.1042/bj1090757. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harlan W. R., Jr, Margraf J. H., Said S. I. Pulmonary lipid composition of species with and without surfactant. Am J Physiol. 1966 Sep;211(3):855–861. doi: 10.1152/ajplegacy.1966.211.3.855. [DOI] [PubMed] [Google Scholar]
- Keenan R. W., Schmidt G., Tanaka T. Quantitative determination of phosphatidal ethanolamine and other phosphatides in various tissues of the rat. Anal Biochem. 1968 Jun;23(3):555–566. doi: 10.1016/0003-2697(68)90246-7. [DOI] [PubMed] [Google Scholar]
- LEFFLER H. H. Estimation of cholesterol in serum. Am J Clin Pathol. 1959 Apr;31(4):310–313. doi: 10.1093/ajcp/31.4.310. [DOI] [PubMed] [Google Scholar]
- MYRVIK Q., LEAKE E. S., FARISS B. Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity. J Immunol. 1961 Feb;86:128–132. [PubMed] [Google Scholar]
- Manktelow B. W. The loss of pulmonary surfactant in paraquat poisoning: a model for the study of the respiratory distress syndrome. Br J Exp Pathol. 1967 Jun;48(3):366–369. [PMC free article] [PubMed] [Google Scholar]
- Morgan T. E., Finley T. N., Huber G. L., Fialkow H. Alterations in pulmonary surface active lipids during exposure to increased oxygen tension. J Clin Invest. 1965 Nov;44(11):1737–1744. doi: 10.1172/JCI105281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PAVILLARD E. R. In vitro phagocytic and bactericidal ability of alveolar and peritoneal macrophages of normal rats. Aust J Exp Biol Med Sci. 1963 Jun;41:265–274. doi: 10.1038/icb.1963.26. [DOI] [PubMed] [Google Scholar]
- ROWLEY D. Bactericidal activity of macrophages in vitro against Escherichia coli. Nature. 1958 Jun 21;181(4625):1738–1739. doi: 10.1038/1811738b0. [DOI] [PubMed] [Google Scholar]
- SUTER E. The multiplication of tubercle bacilli within normal phagocytes in tissue culture. J Exp Med. 1952 Aug;96(2):137–150. doi: 10.1084/jem.96.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wells M. A., Dittmer J. C. A microanalytical technique for the quantitative determination of twenty-four classes of brain lipids. Biochemistry. 1966 Nov;5(11):3405–3418. doi: 10.1021/bi00875a004. [DOI] [PubMed] [Google Scholar]