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. 1972 Feb;53(1):28–30.

Migration of Macrophages to the Thymus after Cyclophosphamide

G Castaldi, G Zavagli, F Trotta, P Malacarne
PMCID: PMC2072383  PMID: 4111328

Abstract

The thymus macrophages behaviour during cyclophosphamide induced thymic lympholysis has been studied in the mouse previously injected with trypan blue. In these conditions a significant increase of the number of macrophages in the subcapsular zone of the cortical layer of the thymus has been observed. Moreover some macrophages of the cortical layer presented lymphocyte debris in their cytoplasm in addition to particles of trypan blue.

Possible implications of these findings are discussed; a migration of macrophages into the thymus from elsewhere is suggested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blau J. N., Gaugas J. M. Parathymic lymph nodes in rats and mice. Immunology. 1968 May;14(5):763–765. [PMC free article] [PubMed] [Google Scholar]
  2. Brumby M., Metcalf D. Migration of cells to the thymus demonstrated by parabiosis. Proc Soc Exp Biol Med. 1967 Jan;124(1):99–103. doi: 10.3181/00379727-124-31675. [DOI] [PubMed] [Google Scholar]
  3. CASTOLDI G. L., MALACARNE P. ASPECTS CYTOCHIMIQUES ET CYTOG'EN'ETIQUES DU GIGANTISME CELLULAIRE PROVOQU'E PAR LES ANTIMITOTIQUES. Nouv Rev Fr Hematol. 1964 May-Jun;4:395–408. [PubMed] [Google Scholar]
  4. Castaldi G., Zavagli G., Fiocchi O., Trotta F. Giant histiocytes after cyclophosphamide. Experientia. 1970 Mar 15;26(3):300–301. doi: 10.1007/BF01900109. [DOI] [PubMed] [Google Scholar]
  5. Field E. O., Stanley E. M. The migration of cells to the thymus. Acta Haematol. 1966 Apr;35(4):221–231. doi: 10.1159/000209127. [DOI] [PubMed] [Google Scholar]
  6. GARVEY J. S., EITZMAN D. V., SMITH R. T. The distribution of S35-labeled bovine serum albumin in newborn and immunologically tolerant adult rabbits. J Exp Med. 1960 Sep 1;112:533–550. doi: 10.1084/jem.112.3.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GREEN I., BLOCH K. UPTAKE OF PARTICULATE MATTER WITHIN THE THYMUS OF ADULT AND NEW-BORN MICE. Nature. 1963 Dec 14;200:1099–1101. doi: 10.1038/2001099a0. [DOI] [PubMed] [Google Scholar]
  8. Gaugas J. M., Payne S., Wharton F. P. Association of macrophage lipids with Mycobacterium lepraemurium in the mouse thymus and lymph node. Br J Exp Pathol. 1970 Feb;51(1):87–91. [PMC free article] [PubMed] [Google Scholar]
  9. Gaugas J. M., Wharton F. P. Increased lipid in thymic macrophages parasitized by Mycobacterium lepraemurium. Experientia. 1969;25(7):736–738. doi: 10.1007/BF01897595. [DOI] [PubMed] [Google Scholar]
  10. HARRIS J. E., FORD C. E., BARNES D. W., EVANS E. P. EVIDENCE FROM PARABIOSIS FOR AN AFFERENT STREAM OF CELLS. Nature. 1964 Feb 29;201:886–887. doi: 10.1038/201886a0. [DOI] [PubMed] [Google Scholar]
  11. KOSTOWIECKI M. THE THYMIC MACROPHAGES. Z Mikrosk Anat Forsch. 1963;69:585–614. [PubMed] [Google Scholar]
  12. MALACARNE P., CASTALDI G. ASPETTI DELLA RIGENERAZIONE TIMICA DOPO ATROFIA SPERIMENTALE DA PREDNISOLONE NEL TOPO. Policlinico Med. 1964 Aug;71:245–257. [PubMed] [Google Scholar]
  13. MARSHALL A. H., WHITE R. G. The immunological reactivity of the thymus. Br J Exp Pathol. 1961 Aug;42:379–385. [PMC free article] [PubMed] [Google Scholar]
  14. Mauss H. Les modifications du thymus au cours de la tuberculose expérimentale de la souris. C R Acad Sci Hebd Seances Acad Sci D. 1968 Mar 18;266(12):1345–1348. [PubMed] [Google Scholar]

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