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. 1972 Oct;53(5):509–517.

The Effect of Clofibrate on Cholesterol Induced Aortic Lesions

J Fehér, Magdolna Bihari-Varga, Mária Varsáńyi, S Gerö
PMCID: PMC2072480  PMID: 4263718

Abstract

The effect of administration of clofibrate was studied in cholesterol fed rabbits. A mathematically very highly significant reduction of the serum lipid level was found following 2 weeks of clofibrate treatment. In the aortas of cholesterol fed rabbits a slight accumulation of intimal glycosaminoglycans together with intensive lipid deposition was found by histological, histochemical and electron microscopic methods. The intracellular lipid substances were present in 4 distinct forms: ring, solid, reticulated and lysosomal. Following treatment with clofibrate, a protofibrillar structure could be demonstrated in the fibroblast-like cells by electron microscopy. At the same time the lipid accumulation and the number of foam cells were decreased.

The results agree closely with those obtained by chemical methods described by us previously.

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